The authors examined 10 healthy male subjects with dynamic computed tomography to determine normal dynamic and expiratory findings. In both the supine and prone positions, the average increase in lung attenuation during exhalation was found to be significantly greater in dependent lung regions than in nondependent lung regions. In each of the lung zones studied, there was a significant correlation between the decrease in cross-sectional lung area during exhalation and the increase in lung attenuation. At the lung bases, a greater increase in lung attenuation was noted during exhalation for a given change in cross-sectional lung area than in the upper lungs. All 10 subjects showed a distinct lobar attenuation gradient in the supine position. In general, lung attenuation increased homogeneously during exhalation, but four of the 10 subjects showed regions of inhomogeneity in lung attenuation during rapid exhalation indicative of air trapping, despite normal results on pulmonary function tests.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1148/radiology.186.1.8416550 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Corrigendum to "Isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate protects lipopolysaccharide-induced acute lung injury in mice by attenuating pyroptosis" [Eur. J. Pharmacol. 5 (2023) 175545].
Eur J Pharmacol
January 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, 229 Taibai North Road, Xi'an, 710069, PR China. Electronic address:
The interaction between antithrombin and endothelial heparan sulfate mitigates pulmonary thromboinflammation after trauma and hemorrhagic shock.
Shock
January 2025
The University of Alabama, Birmingham, Department of Surgery and Center for Injury Science, Division of Trauma and Acute Care Surgery, Birmingham, AL.
Introduction: Trauma and hemorrhagic shock (T/HS) are associated with multiple organ injury. Antithrombin (AT) has anti-inflammatory and organ protective activity through its interaction with endothelial heparan sulfate containing a 3-O-sulfate modification. Our objective was to examine the effects of T/HS on 3-O-sulfated (3-OS) heparan sulfate expression and determine whether AT-heparan sulfate interactions are necessary for its anti-inflammatory properties.
View Article and Find Full Text PDFDesign, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury.
J Med Chem
January 2025
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong 510260, China.
Pulmonary inflammation is the main cause of lung injury. Phosphodiesterase 4 (PDE4) is a promising anti-inflammatory target for the treatment of respiratory diseases. Herein, we designed and synthesized 43 compounds in two novel series of benzimidazole derivatives as PDE4 inhibitors.
View Article and Find Full Text PDFLifelike and Deformable Lung Phantoms for 4DCT Imaging: A Three-Dimensional Printing Approach.
Conf Proc Int Conf Image Form Xray Comput Tomogr
August 2024
Department of Radiology, Perelman School of Medicine, Philadelphia, PA, USA.
Respiratory motion phantoms can be used for evaluation of CT imaging technologies such as motion artifact reduction algorithms and deformable image registration. However, current respiratory motion phantoms do not exhibit detailed lung tissue structures and thus do not provide a realistic testing environment. This paper presents PixelPrint, a method for 3D-printing deformable lung phantoms featuring highly realistic internal structures, suitable for a broad range of CT evaluations, optimizations, and research.
View Article and Find Full Text PDFHMGB1 secretion by resveratrol in NSCLC: A pathway to ferroptosis-mediated platelet activation suppression.
Cell Signal
January 2025
Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:
Background: Cancer-associated venous thromboembolism (CAT) is a frequent and serious complication in cancer patients. Resveratrol, a natural compound with reported anti-tumor effects, is not fully understood in its role regarding CAT in lung cancer. This study aims to explore resveratrol's potential to diminish platelet activation induced by lung adenocarcinoma cells and uncover the underlying mechanisms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!