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Induction of Oral Lichen Planus-like Histopathology in Mice.
J Dent Res
December 2024
Department of Immunology and Molecular Microbiology in Dental Science, Seoul National University School of Dentistry, Seoul, Republic of Korea.
Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory mucosal disease of unknown etiology. The lack of suitable animal models has hampered understanding of its etiopathogenesis. This study aimed to clarify the contribution of bacterial infection and zinc deficiency (ZD) in OLP pathogenesis by developing a murine model.
View Article and Find Full Text PDFXAF1 is secreted from stressed tumor cells to activate T cell-mediated tumor surveillance via Lck-ERK signaling.
Neoplasia
January 2025
Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea. Electronic address:
X-linked inhibitor of apoptosis-associated factor 1 (XAF1) is a stress-inducible tumor suppressor that is commonly inactivated in multiple types of human malignancies. Nevertheless, the molecular basis for the XAF1-mediated tumor suppression remains largely undefined. Here, we report that XAF1 is secreted from cells under various cytotoxic stress conditions and activates T cell-mediated tumor surveillance.
View Article and Find Full Text PDFIntracellular zinc protects tumours from T cell-mediated cytotoxicity.
Cell Death Differ
December 2024
Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Article Synopsis
- Tumours evade immune responses, making cancer immunotherapies less effective, mainly through loss of antigen presentation and cytokine signaling pathways.
- A genome-wide CRISPR/Cas9 screen identified that loss of core-binding factor subunit beta (CBFβ) increases tumour resistance to CAR-T cells, which do not rely on traditional antigen presentation.
- The study found that intracellular zinc levels influence tumour cell susceptibility to T cell killing, suggesting that targeting zinc could enhance the effectiveness of cancer therapies in overcoming immune evasion.
Replacing Inorganic Source of Zinc with Zinc Hydroxy Chloride: Effects on Health Status, Hemato-biochemical Attributes, Antioxidant Status, and Immune Responses in Pre-ruminant Crossbred Calves.
Biol Trace Elem Res
August 2024
Animal Nutrition Division, ICAR- National Dairy Research Institute, Karnal, Haryana, India.
Article Synopsis
- The study evaluated the use of Zn hydroxy chloride (ZnOHCl) as a potential replacement for Zn sulfate (ZnSO) in the diet of pre-ruminant crossbred calves to assess its effects on health and nutritional status.
- Twenty-four male calves were divided into four groups, receiving different levels and sources of zinc supplementation over a 90-day period, while all were fed according to established nutrient standards for growth.
- Results showed no significant health status changes or hematological differences across the groups, but zinc supplementation improved certain biochemical markers and enhanced total antioxidant capacity and immune responses, with no notable differences among the types of zinc administered.
Ibuprofen-Induced Pancytopenia and Erythema Multiforme in an Elderly Female Patient.
Cureus
June 2024
Internal Medicine, Hospital Corporation of America (HCA) Healthcare Oak Hill Hospital, Brooksville, USA.
Article Synopsis
- - Erythema multiforme (EM) is a skin condition that can occur due to infections, medications, vaccines, or autoimmune diseases, with NSAIDs like ibuprofen having rare associations with it and resultant pancytopenia (low blood cell counts).
- - A 75-year-old woman developed EM and pancytopenia after taking ibuprofen for shoulder bursitis, presenting with neck swelling, a target-shaped rash, and oral ulcers 15 days post-medication.
- - After discontinuing ibuprofen and providing supportive care, including blood transfusions, the patient’s condition improved, and she was discharged six days later, highlighting the need for awareness of rare NSAID side effects among healthcare professionals.
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