The measurement of arterial blood oxygen tension (PaO2) in 54 patients with chronic nonspecific lung disease with a FEV1.0 of 1.51 or less, in a stable clinical state, at rest, indicated subnormal results to be more frequent among "bronchitics" (79 per cent with hypoxemia) than than among "emphysematous" patients (63 per cent with hypoxemia). The patients were classified according to a mixed clinical-roentgenologic-biological "score" (Nash et al., 1965). A significant correlation was found between PaO2 and the "emphysema score" (r=0.36; p less than 0.01). The average PaO2 was significantly (p less than 0.02) lower in "bronchitics" (65.5 +/- 8.8 mmHg; n = 14) as compared to the "emphysema" group (71.8 +/- 5.7; n = 19), in agreement with the data of the literature.
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J Natl Cancer Cent
December 2024
Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Background: Tumor-derived exosomes are involved in tumor progression and immune invasion and might function as promising noninvasive approaches for clinical management. However, there are few reports on exosom-based markers for predicting the progression and adjuvant therapy response rate among patients with clear cell renal cell carcinoma (ccRCC).
Methods: The signatures differentially expressed in exosomes from tumor and normal tissues from ccRCC patients were correspondingly deregulated in ccRCC tissues.
BMJ Open
November 2024
Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden.
Unlabelled: Obstructive sleep apnoea (OSA) and its associations with lung function.
Background: OSA is highly prevalent and characterised by abnormal respiration during sleep. This large, population-based study aimed to investigate the associations between OSA and lung function in subjects aged 50-64 years.
Proc (Bayl Univ Med Cent)
July 2024
Department of Internal Medicine, University of Massachusetts Chan Medical School, Springfield, Massachusetts, USA.
Background: Clinical judgment is essential in determining the need for specialist consultation. We evaluated patients for whom the pulmonary team was consulted for unspecified hypoxia or acute hypoxic respiratory failure to better understand the characteristics and outcomes of such encounters.
Methods: We retrospectively studied patients who received consults for unspecified hypoxia or acute hypoxic respiratory failure at a tertiary center.
J Cent Nerv Syst Dis
August 2024
Research and Development Laboratory, Simmaron Research Institute, Milwaukee, WI, USA.
Background: Tetrahydrobiopterin (BH4) and its oxidized derivative dihydrobiopterin (BH2) were found to be strongly elevated in ME/CFS patients with orthostatic intolerance (ME + OI).
Objective: However, the molecular mechanism of biopterin biogenesis is poorly understood in ME + OI subjects. Here, we report that the activation of the non-oxidative pentose phosphate pathway (PPP) plays a critical role in the biogenesis of biopterins (BH4 and BH2) in ME + OI subjects.
J Tehran Heart Cent
October 2023
Center for Applied Molecular Biology, University of the Punjab, Lahore, Pakistan.
Background: Several studies have investigated the role of vascular endothelial growth factor (VEGF) variants, serum levels, and correlations with other extrinsic factors in congenital heart defects (CHDs); however, the findings need confirmation. The present systematic review evaluates the association between CHDs and genetic polymorphisms and serum expressions.
Methods: Relevant literature was searched through electronic databases using keywords and MeSH terms.
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