AI Article Synopsis
- Capsaicin, a neurotoxin derived from plants, has been shown to affect human neutrophil migration, particularly enhancing it at specific concentrations.
- A significant increase in migration was observed with 10(-8) M capsaicin and peak activity at 10(-6) M, indicating a direct effect on neutrophils not involving neuropeptides.
- Higher concentrations of capsaicin did not further affect migration and did not influence superoxide anion generation in neutrophils, as shown by unchanged chemiluminescence results.
Article Abstract
Capsaicin, a homovanillic acid derivative in plants, has distinct pharmacological effects in vivo, e.g. it depletes primary afferent neurons of substance P and other tachykinins. The effect of capsaicin on the migration of human neutrophils was tested in concentrations ranging from 10(-8) M to 10(-3) M. In comparison to the control 10(-8) M capsaicin significantly enhanced the migration of PMN cells (CI 1.29; 2P < 0.009) and a peak migration activity was detected with 10(-6) M (CI 1.32; 2P < 0.01). With higher concentrations of capsaicin the CI was not significantly changed. These results show that capsaicin, a plant derived neurotoxin, exhibits a migration modifying activity on human neutrophils through a direct mechanism not mediated by neuropeptides. In addition capsaicin (10(-7) and 10(-5) M) did not affect the luminol-dependent chemiluminescence and therefore does not contribute to a superoxide anion generation in human PMN.
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| http://dx.doi.org/10.1016/0024-3205(93)90625-d | DOI Listing |
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