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Reciprocal Interaction with Neutrophils Facilitates Cutaneous Accumulation of Liposomes.
ACS Nano
July 2024
Department of Pharmacology, School of Basic Medical Sciences & Department of Pharmacy, Shanghai Pudong Hospital, Fudan University, Shanghai 200032, P. R. China.
Article Synopsis
- - Liposomes are effective drug delivery systems for cancer treatment, but PEGylated liposomal doxorubicin (sLip/DOX) causes skin toxicities due to their accumulation in the dermis.
- - The interaction between liposomes and neutrophils is crucial for liposome movement into the skin, as neutrophils recognize and capture liposomes via specific receptors.
- - By inhibiting complement activation or altering liposome surface properties, researchers found ways to reduce neutrophil uptake of liposomes, which may help decrease skin toxicity associated with sLip/DOX use.
Clinical overview of phototherapy for neonatal hyperbilirubinaemia.
Acta Paediatr
October 2024
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
The most efficient emission spectrum of light for phototherapy is blue-green light emission diode light with peak emission at 478 nm. In the irradiance interval of phototherapy, the relationship between efficacy and irradiance is almost linear, and it is negatively related to the haemoglobin. The action sites of phototherapy are the extravascular compartment and cutaneous blood.
View Article and Find Full Text PDFForeign body granulomas following endovascular treatment are rare complications and are mostly reported in the brain or cutaneous vascular tissues. To the best of our knowledge, no study to date has reported on foreign body granulomas in the abdomen after injection of N-butyl-2-cyanoacrylate (NBCA)-lipiodol mixture into the abdominal arteries. This study reports a case of foreign body granuloma that appeared 12 months after the embolization of a right internal iliac artery aneurysm using an NBCA-lipiodol mixture, which posed challenges in differentiation from malignant tumors.
View Article and Find Full Text PDFCan angiotropism and lymphovascular invasion refine the current cutaneous melanoma staging system?
J Cutan Pathol
April 2024
Cellular Pathology Department, Nottingham University Hospital, Nottingham, UK.
Background: Several prognostic factors for primary cutaneous melanoma (PCM) have been identified, and these predict metastasis and survival, to a certain extent. We sought to determine the frequency of angiotropism (AT) and lymphovascular invasion (LVI) in PCM and the relationship between AT, LVI, and other clinicopathological parameters and patient's prognosis.
Methods: This study included 538 cases of PCM diagnosed between 2003 and 2016.
Rituximab-ameliorated Cutaneous Extravascular Necrotizing Granuloma.
Intern Med
May 2024
Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
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