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Emerging roles for tubulin PTMs in neuronal function and neurodegenerative disease.
Curr Opin Neurobiol
January 2025
Department of Pathology & Cell Biology, Columbia University Irving Medical Center, 10032, New York, NY, USA. Electronic address:
Neurons are equipped with microtubules of different stability with stable and dynamic domains often coexisting on the same microtubule. While dynamic microtubules undergo random transitions between disassembly and assembly, stable ones persist long enough to serve as platforms for tubulin-modifying enzymes (known as writers) that attach molecular components to the α- or β-tubulin subunits. The combination of these posttranslational modifications (PTMs) results in a "tubulin code," dictating the behavior of selected proteins (known as readers), some of which were shown to be crucial for neuronal function.
View Article and Find Full Text PDFCoping after the COVID-19 pandemic: nurses' learning intent and implications for the workforce and education.
Br J Nurs
January 2025
Professor, Department of Nursing, Beaver College of Health Sciences, Appalachian State University, Boone, North Carolina, USA.
Background/aim: Addressing the critical global shortage of nurses requires an understanding of how a global pandemic reshaped nurses' motivations and intentions toward education. This study aimed to describe COVID-19's impact on nurses' intent to pursue additional education.
Method: This descriptive study, based in North Carolina in the USA, used content analysis with an inductive approach to examine the responses of nurses to one open-ended question in a large quantitative workforce survey: how has COVID-19 influenced your plans for future education? Responses were coded with counts and organised into themes and subthemes.
Unmet Needs in the Management of Chronic Kidney Disease-Associated Pruritus and the Characteristics of the Ideal Treatment: A Spanish Cross-Sectional Survey from a Multidisciplinary Perspective.
J Clin Med
January 2025
Management, Association for the Fight against Kidney Diseases ALCER, 28002 Madrid, Spain.
Chronic kidney disease-associated pruritus (CKD-aP) is underdiagnosed and not fully understood by healthcare professionals, which leads to poor patient management and impacts patients' quality of life (QoL). The aim of this study was to analyse unmet needs in CKD-aP management and explore the attributes/characteristics that the ideal CKD-aP treatment should have from the perspective of a group of nephrologists, hospital pharmacists, nurses, patient representatives, and regional health authorities in Spain. A descriptive, cross-sectional study was conducted using an e-survey including ad hoc questions (6-point Likert scale) related to unmet needs in CKD-aP and best-worst scaling (BWS) to prioritise the attributes/characteristics of the ideal CKD-aP treatment.
View Article and Find Full Text PDFPatterns of balancing and compensating primary tooth extractions among paediatric dentists.
Br Dent J
January 2025
Professor in Orthodontics, University of Ulster, Faculty of Life and Health Sciences, College of Medicine and Dentistry, 32‑34 Colmore Circus, Birmingham, B4 6BN, UK.
Introduction Balancing and compensating extractions (BCEs) of primary teeth aims to minimise the development of more severe malocclusions and reduce the need for subsequent complex orthodontics.Purpose To assess the demographics, practice characteristics and clinical preferences of United Kingdom paediatric dentists for BCEs of primary teeth.Methods All members of the British Society of Paediatric Dentistry were sent an electronic questionnaire.
View Article and Find Full Text PDFCrystallisation Based Deracemisation and Chiral Resolution of Small Molecules.
Chem Asian J
January 2025
Mahatma Gandhi University, School of Chemical Sciences, Priyadarsini Hills, 686560, Kottayam, INDIA.
Enantiomeric separation of chiral molecules is pivotal for exploring fundamental questions about life's origin and many other fields. Crystallisation is an important platform for the separation of chiral molecules, elegantly applied to many systems, for instance, the formation of conglomerates, where the enantiomers crystallise as separate phases. Many approaches have been proposed to explore crystallisation-driven enantiomeric separation with fewer insights into the complex pathways associated with the separation processes.
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