The effect of midazolam on motility of the sphincter of Oddi in human subjects.
Endoscopy
Service d'Hépato Gastro Entérologie, Clermont-Ferrand, France.
Published: August 1993
Midazolam, a water-soluble benzodiazepine, has recently been introduced and found to be beneficial for sedation in upper GI endoscopy. Whereas it has been proven that diazepam does not have any effect on sphincter of Oddi (SO) motility in humans, no respective data exist on midazolam. On evaluation of the possible effects of midazolam on SO motility recording by means of endoscopic manometry, we found that midazolam had no effect on basal pressure (24.2 +/- 12.59 mm Hg before and 23.85 +/- 12.63 mm Hg after midazolam, p = 0.55), amplitude (39.75 +/- 22.62 versus 44.55 +/- 27.15, p = 0.097), duration (4.9 +/- 1.8 sec versus 5.05 +/- 1.7 sec, p = 0.614), and frequency of SO contractions (7.75 +/- 1.68 waves/min versus 7.15 +/- 1.92 waves/min, p = 0.083). These results suggest that in patients with normal manometric findings midazolam does not interfere with SO recording.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-2007-1010345 | DOI Listing |
Similar Publications
Antibiotic-induced decrease of bacterial load in guinea pig intestine reduces α-adrenoceptor expression and activity in peristaltic motor inhibition.
Br J Pharmacol
February 2025
Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Background And Purpose: The use of analgosedatives in critically ill patients carries the risk of impairing gastrointestinal (GI) propulsion and could thereby lead to sepsis. The gut microbiota can influence GI motility, but whether GI microbial dysbiosis modifies GI peristalsis impairment by analgosedative drugs has not yet been analysed. This question was addressed in the guinea pig small intestine following a decrease of bacterial load by antibiotic pretreatment.
View Article and Find Full Text PDFThe Esophageal Response to Distension on Functional Lumen Imaging Probe Panometry Is Minimally Changed by Conscious Sedation in Healthy Asymptomatic Subjects.
J Neurogastroenterol Motil
January 2025
Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Rockford, IL, USA.
Background/aims: Functional lumen imaging probe (FLIP) Panometry has demonstrated utility in the assessment of esophageal motility as a complement to existing methodologies like high-resolution manometry. However, as FLIP is typically performed with sedation during routine endoscopy, there is potential for impact of sedation agents on esophageal motility. We aim to examine the effects of conscious sedation with midazolam and fentanyl on FLIP Panometry metrics and classification.
View Article and Find Full Text PDFInfluences of different sedatives on gastric antrum contraction in patients with acute brain injury.
Front Neurol
December 2024
Neurosurgery ICU, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Patients with acute brain injury (ABI) often exhibit gastrointestinal motility disorder and the administration of sedatives may exacerbate the gastrointestinal dysfunction. This study aims to evaluate the influences of different sedatives on gastric antrum contraction in patients with acute brain injury (ABI).
Methods: A prospective observational study was performed in 37 adult ICU patients with ABI, and 18 adult healthy volunteers were recruited as normal controls.
Endoscopic Sedation Type During FLIP Panometry Does Not Significantly Impact FLIP Motility Classification Relative to Manometry.
Clin Gastroenterol Hepatol
November 2024
Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
Background & Aims: Functional lumen imaging probe (FLIP) panometry evaluates esophageal motility at the time of sedated endoscopy and often parallels high-resolution manometry (HRM) performed in awake patients. This study aimed to assess the impact of endoscopic sedation on FLIP evaluation of esophageal motility.
Methods: Adult patients who completed FLIP panometry during sedated endoscopy and had a conclusive Chicago Classification version 4.
The Effect of Dexmedetomidine Sedation on Lower Gastrointestinal Motility in Children-Is It Suitable for Anorectal Manometry?
J Clin Med
December 2023
Department of Anaesthesia, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Anorectal manometry is one of the most frequently performed gastrointestinal motility studies in children. It is an important study in diagnosing Hirschsprung disease (HD). These procedures can be uncomfortable, painful and emotionally distressing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.