AI Article Synopsis
- Cytogenetic analysis is crucial for predicting outcomes in children with blood cancers.
- A previously unreported case of acute lymphoblastic leukemia involved a rare three-way translocation of chromosomes 4, 11, and 13.
- This case adds new information to the understanding of genetic factors in pediatric leukemia.
Article Abstract
Cytogenetic analysis provides valuable prognostic information in children diagnosed with hematologic malignancies. While the t(4;11)(q21;q23) has frequently been reported in patients with acute lymphoblastic leukemia, the additional involvement of chromosome 13 to form a three-way translocation has not been described previously. We report a case of acute lymphoblastic leukemia in a 5-month old infant with a complex t(4;11;13)(q21;q23;q12-14).
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| http://dx.doi.org/10.1016/0165-4608(93)90094-3 | DOI Listing |
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