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Therapeutic Drug Monitoring of High-dose Sulbactam in Pediatric Patients: Preliminary Data From a Prospective Observational Pharmacokinetic Study.
Pediatr Infect Dis J
October 2024
From the Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine.
Background: Rates of carbapenem-resistant Acinetobacter baumannii are rising in Thailand. Although high-dose (HD) sulbactam is recommended for treating carbapenem-resistant A. baumannii infections, data on plasma sulbactam concentrations in children are limited.
View Article and Find Full Text PDFThe First Triple Agonist for Antiobesity: Retatrutide.
Cardiol Rev
October 2024
From the School of Medicine, New York Medical College, Valhalla, NY.
The prevalence of individuals with overweight and obesity has increased by 18% since 1990 and it is projected that by 2030, nearly 50% of US adults will have obesity. Lifestyle modifications, such as diet and exercise, typically lead to approximately 3-5% weight loss, whereas 5-15% weight loss is necessary to significantly impact obesity-associated comorbidities and improve overall health outcomes. In addition to lifestyle modifications, pharmacotherapy has been utilized as an adjunctive treatment to increase weight loss and improve health outcomes.
View Article and Find Full Text PDFPotential antioxidant properties and computational molecular interactions of Moringa oleifera against abamectin-induced oxidative stress in rat erythrocytes and brain.
Chem Biodivers
December 2024
University of Badji Mokhtar Annaba Department of Biochemistry, Biochemistry, Annaba, 213, Annaba, ALGERIA.
The current study was conducted to explore the phytochemical composition and in vitro antioxidant activities of Moringa oleifera (MO) leaf aqueous extract, as well as its in vivo modulatory effects on abamectin (ABM) induced oxidative stress in rat erythrocytes and brain. Animals were randomly divided into four groups. The first group served as a control and received distilled water by gavage.
View Article and Find Full Text PDFTwo cases of fatal insulin homicide resolved using combined immunohistochemistry and immunofluorescence techniques.
Forensic Sci Med Pathol
December 2024
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, People's Republic of China.
Diabetes is a prevalent disease in modern society. Since the development and widespread use of synthetic insulin, its therapeutic application has become globally recognized for managing diabetes. However, excessive administration of insulin may lead to fatal outcomes.
View Article and Find Full Text PDFVariations in serum concentrations of sunitinib and its metabolites in patients receiving long-term sunitinib treatment.
Cancer Chemother Pharmacol
December 2024
Division of Pharmacotherapeutics, Department of Clinical Pharmacy, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Purpose: The blood concentrations of some tyrosine kinase inhibitors are known to decrease with long-term administration. We evaluated the variability in the serum concentrations of sunitinib and its metabolites in patients receiving long-term sunitinib treatment.
Methods: This study prospectively recruited patients who received sunitinib for metastatic renal cell carcinoma at the Showa University Hospital between March 2020 and January 2022.
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