Eighteen patients suffering from an advanced colorectal cancer were treated with 5 days continuous venous infusion of ifosfamide and mesna (1 g/m2, 5/21 days). All had previously received 5-fluorouracil-based chemotherapies. Disposable programmable infusion pumps (Cadd-I, Pharmacia Deltec and Intelliject Multisyringe) allowed ambulatory administration of the treatment. Toxicity was manageable; we had mainly to deplore two cases of grade 3 central nervous system manifestations. Only one minor response (lung lesions) and one no change were evidenced. We conclude that for this type of patient, ifosfamide has very limited antitumor activity. Nevertheless, we demonstrated the safety and feasibility of the proposed ambulatory schedule which could be used in other oncological indications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00001813-199308000-00006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Glycemic control in women with GDM: insights from a randomized controlled pilot trial on plant-based Nordic healthy diet versus moderately carbohydrate restricted diet.
BMC Nutr
January 2025
Department of Food and Nutrition, University of Helsinki, Helsinki, Finland.
Background: Gestational Diabetes Mellitus (GDM) prevalence is rising worldwide, but optimal dietary strategies remain unclear. The eMOM pilot RCT compared a plant-protein rich Healthy Nordic Diet (HND) and a moderately carbohydrate restricted diet (MCRD) and their potential effects on time in glucose target range (≤ 7.8 mmol/L, %TIR), and on newborn body composition.
View Article and Find Full Text PDFRisk of Vertebral Fracture in Individuals with End-Stage Renal Disease Secondary to Vasculitis.
Kidney360
January 2025
Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Background: Glucocorticoids are central to vasculitis treatment but increase vertebral fracture risk. This study assessed whether vasculitis as the cause of ESRD is associated with incident vertebral fracture, controlling for corticosteroid use.
Methods: A retrospective cohort study was conducted from 2006-2019 on adults in the U.
Smart release injectable hydrogel co-loaded with liposomal combretastatin A4 and doxorubicin nanogel for local combinational drug delivery: A preclinical study.
Int J Pharm
January 2025
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Surgical resection and postoperative adjuvant chemotherapy have enhanced the outlook for breast cancer patients. However, tumor relapse and serious side effects of chemotherapy continue to impact patients' quality of life. Designing injectable composite hydrogel made of biodegradable polymers providing sustained release of antiangiogenic and chemotherapeutic agents might play a vital role in elimination of cancer cells.
View Article and Find Full Text PDFThe Limited Utility of Hemoglobin A1c as a Predictor for Periprosthetic Joint Infection Following Total Joint Arthroplasty: A Continuous Variable Analysis.
J Arthroplasty
January 2025
Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California. Electronic address:
Introduction: Patients who have poorly controlled diabetes mellitus are at increased risk of periprosthetic joint infection (PJI). Nevertheless, an optimal preoperative hemoglobin A1c (HbA1c) threshold has not been established. This study sought to identify preoperative HbA1c thresholds that were predictive of adverse outcomes for total hip (THA) and total knee arthroplasty (TKA) patients.
View Article and Find Full Text PDFOccurrence of emerging and persistent organic pollutants in the rivers Cam, Ouse and Thames, UK.
Sci Total Environ
January 2025
Centre for Agroecology Water and Resilience (CAWR), Coventry University, Wolston Lane, Ryton on Dunsmore, CV8 3LG, UK. Electronic address:
The widespread occurrence of new and emerging and persistent organic pollutants (NEPs and POPs) in surface water poses a risk to drinking water supply and consequently human health. The aim of this work was to investigate the occurrence and potential transport of 42 target NEPs and POPs (including per-and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides and bisphenols) along the rural and urban environments of three rivers in England. The type and concentrations of pollutants varied between the sampling days and points.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!