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Potential roles of mitochondrial carrier proteins in plant responses to abiotic stress.
J Exp Bot
January 2025
National Institute of Science and Technology on Plant Physiology under Stress Conditions, Departamento de Biologia Vegetal, Universidade Federal de Viçosa, Viçosa 36570-900, Minas Gerais, Brazil.
The transport of metabolites across the inner mitochondrial membrane (IMM) is crucial for maintaining energy balance and efficient distribution of metabolic intermediates between cellular compartments. Under abiotic stress, mitochondrial function becomes particularly critical, activating complex signaling pathways essential for plant stress responses. These pathways modulate stress-responsive gene expression, influencing key physiological processes such as cell respiration and senescence, helping plants adapt to stress.
View Article and Find Full Text PDFEpidemiology of invasive candidiasis before and during the COVID-19 pandemic at a hospital in southeastern Brazil.
J Infect Dev Ctries
December 2024
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
Introduction: Invasive candidiasis is an important cause of nosocomial infection and recent studies have shown an increase in the number of cases during the coronavirus disease 2019 (COVID-19) pandemic. The present study aimed to evaluate the epidemiology and incidence of invasive candidiasis before and during the COVID-19 pandemic at a reference tertiary hospital in Brazil.
Methodology: A retrospective observational study was performed with 148 patients infected with Candida spp.
Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival.
Cell Commun Signal
January 2025
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. Here, we investigated a potent small molecule inhibitor to Class I glucose transporters, KL-11743, using glycolytic leukemia cell lines and patient-based model systems.
View Article and Find Full Text PDFAutomated mechanical ventilator design and analysis using neural network.
Sci Rep
January 2025
School of Computing, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.
Mechanical ventilation is the process through which breathing support is provided to patients who face inconvenience during respiration. During the pandemic, many people were suffering from lung disorders, which elevated the demand for mechanical ventilators. The handling of mechanical ventilators is to be done under the assistance of trained professionals and demands the selection of ideal parameters.
View Article and Find Full Text PDFPhysiological and behavioral effects of titanium dioxide nanoparticle exposure on stingless bee foragers.
J Hazard Mater
January 2025
Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, MG, Brazil. Electronic address:
Bee population decline is associated with various stressors, including exposure to pollutants. Among these, titanium dioxide (TiO), an emerging nanoparticle (NP) pollutant, potentially affects living organisms, including bees. This study evaluates the impact of TiO NPs ingestion (1.
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