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Signal detection of drugs associated with obstructive and central sleep apnoea.
Sleep Med
December 2024
Grenoble Alpes University Hospital, Pharmacovigilance Unit, F-38000, Grenoble, France; Univ. Grenoble Alpes, HP2 Laboratory, Inserm U1300, F-38000, Grenoble, France; Grenoble Alpes University Hospital, Clinical Pharmacology Department INSERM CIC1406, F-38000, Grenoble, France. Electronic address:
We aim to discover new safety signals of drug-induced sleep apnoea (SA), a global health problem affecting approximately 1 billion people worldwide. We first conducted a series of sequence symmetry analyses (SSA) in a cohort composed from all patients who received a first SA diagnosis or treatment between 2006 and 2018 in the Echantillon Généraliste des Bénéficaires (EGB), a random sample of the French healthcare database. We used two primary outcomes to estimate the sequence ratio (SR) for all drug classes available in France: a sensitive one (diagnosis or treatment of SA) and a specific one (Positive Airway Pressure (PAP) therapy).
View Article and Find Full Text PDFDisseminated Intravascular Coagulation Due to Drinking Tonic Water.
Cureus
December 2021
Internal Medicine, Indiana University Health Ball Memorial Hospital, Muncie, USA.
Article Synopsis
- Quinine is traditionally used to treat malaria but is now also used for nighttime muscle cramping, found in tonic water and other products.
- Quinine can have side effects, including serious conditions like disseminated intravascular coagulation.
- A case is presented of a 35-year-old man who developed this condition from excessive tonic water intake, highlighting the need for doctors to be aware of quinine's side effects during patient evaluations.
Non-drug therapies for the secondary prevention of lower limb muscle cramps.
Cochrane Database Syst Rev
May 2021
University of Sydney School of Health Sciences, Faculty of Medicine and Health, Sydney, Australia.
Background: Lower limb muscle cramps are common and painful. They can limit exercise participation, and reduce quality of sleep, and quality of life. Many interventions are available for lower limb cramps; some are controversial or could cause harm, and often, people experience no benefit from the interventions used.
View Article and Find Full Text PDFISCEV extended protocol for the photopic On-Off ERG.
Doc Ophthalmol
June 2018
Department of Electrophysiology, Moorfields Eye Hospital, London, UK.
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On-Off ERG, and outlines common clinical applications. A light stimulus duration of 150-200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components.
View Article and Find Full Text PDFFactors associated with contracting malaria in Ward 29 of Shamva District, Zimbabwe, 2014.
S Afr Med J
April 2017
Department of Community Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Background: Malaria cases at Wadzanayi Clinic in Shamva District, Zimbabwe, increased drastically, surpassing the epidemic threshold, in week four of December 2013. This rise was sustained, which necessitated an investigation of the outbreak.
Objectives: To identify risk factors and system weaknesses to improve epidemic preparedness and response.
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