The aesthesioneuroblastoma (olfactory neuroma) is a rare neuroepithelial tumour of the nasal cavity, the clinical symptoms of which become manifest very late in most patients. In general, with the light microscope used routinely (fixation of the specimens with formaldehyde, staining with haematoxylin-eosine) a malignant round cell neoplasia can be recognised without further differentiation. To ensure the diagnosis of an aesthesioneuroblastoma, immunohistological techniques (vimentin, S-100 protein, neurofilaments, neuron-specific enolase) are undoubtedly necessary. In some cases of unclear findings the electron microscope might be used to prove an aesthesioneuroblastoma. The immunohistological and electron microscopic features of aesthesioneuroblastoma are demonstrated and problems of histological differential diagnosis are discussed.
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[Esthesioneuroblastoma: diagnostic conformation by immunohistology and electron microscopy].
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August 1993
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The aesthesioneuroblastoma (olfactory neuroma) is a rare neuroepithelial tumour of the nasal cavity, the clinical symptoms of which become manifest very late in most patients. In general, with the light microscope used routinely (fixation of the specimens with formaldehyde, staining with haematoxylin-eosine) a malignant round cell neoplasia can be recognised without further differentiation. To ensure the diagnosis of an aesthesioneuroblastoma, immunohistological techniques (vimentin, S-100 protein, neurofilaments, neuron-specific enolase) are undoubtedly necessary.
View Article and Find Full Text PDF[Esthesioneuroblastoma: histogenesis and diagnosis].
Strahlenther Onkol
June 1989
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Tumors of the rat induced by means of two different nitrosamines (N-nitrosopiperidine, 2,6-dimethylnitrosomorpholine) were analyzed with the light and electron microscope and by immunohistological investigation. The ultrastructural analysis showed mainly in the Flexner rosettes some clear characteristics of olfactory epithelium such as olfactory vesicles, cilia, and microtubules. With four exceptions, the immunohistologically investigated tumor cells showed no immunofluorescence after incubation with antibodies against intermediate filaments.
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