Cancer of the head and neck has been associated with herpes simplex virus type-1 by serologic studies that have used virus particles or complex mixtures of viral proteins as antigens. Recently a peptide was found to be encoded by the transforming region of the virus that is mutagenic and is postulated to be involved in cell transformation. Sera from young adult patients with head and neck cancer and from control subjects were examined for the presence of antibody to this peptide with the use of an enzyme-linked immunosorbent assay. Antibody to the peptide was detected in many sera and showed a significant correlation with antibody to the virus in sera from control subjects. Antipeptide antibodies were largely of the IgM isotype, and patients had significantly higher levels of antibody than control subjects. This study is consistent with an association between HSV-1 and head and neck cancer and suggests that this viral peptide should be investigated further for its role in carcinogenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0030-4220(93)90235-v | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ultrasound-Assisted Transclival Resection of Clival Chordoma With Intradural Extension: A 3-Dimensional Operative Video.
Oper Neurosurg (Hagerstown)
November 2024
Department of Neurological Surgery, Wexner Medical Center at The Ohio State University, Columbus, Ohio, USA.
Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival.
Science
January 2025
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, suggesting separate mechanisms are involved. Here, we found that the transcription factor Casz1 was crucial for early IHC fate consolidation and for OHC survival during mouse development. Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production.
View Article and Find Full Text PDFInfluence of Messa di Voce speed on vocal stability of untrained, healthy subjects.
PLoS One
January 2025
Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Munich University Hospital (LMU), Munich, Germany.
Introduction: Despite its importance in voice training, comprehensive research into sustained vowel phonation with constant pitch and increasing and decreasing loudness, the so-called Messa di Voce, is lacking. The study examines the laryngeal behavior during Messa di Voce, regarding the impact of the speed of execution on voice stability parameters.
Materials And Methods: Nine untrained, healthy subjects (5 female, 4 male) were asked to perform Messa di Voce exercises on the vowel [i:], involving a gradual increase and decrease of volume.
Carotid artery stenosis and ischemic cerebrovascular events after radiotherapy in patients with head and neck cancer.
PLoS One
January 2025
Department of Radiation Oncology, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand.
Radiotherapy is the main treatment for patients with head and neck cancer (HNC) and is associated with an increased risk of ischemic cerebrovascular events (ICVE). The purpose of this cross-sectional study was to determine the incidence of ICVE and carotid artery stenosis (CAS) in patients with HNC who receive radiotherapy and the risk factors for CAS. We enrolled 907 patients with HNC who underwent radiotherapy between February 2011 and June 2022 and obtained information on their clinical and tumor characteristics and their treatment from the clinical records.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!