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Vi capsular polysaccharide of Salmonella enterica serovar Typhi disturbs autophagy to increase intracellular survival in macrophages.
Microb Pathog
February 2025
Department of Laboratory Medicine, Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212001, China. Electronic address:
The autophagy pathway plays a crucial role in resistance to bacterial infection in the host. Salmonella enterica serovar Typhi (S. Typhi), a human restricted pathogen, causes a systemic infection known as typhoid fever.
View Article and Find Full Text PDFA newly developed oral infection mouse model of shigellosis for immunogenicity and protective efficacy studies of a candidate vaccine.
Infect Immun
December 2024
Division of Clinical Medicine, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, West Bengal, India.
infection poses a significant public health challenge in the developing world. However, lack of a widely available mouse model that replicates human shigellosis creates a major bottleneck to better understanding of disease pathogenesis and development of newer drugs and vaccines. BALB/c mice pre-treated with streptomycin and iron (FeCl) plus desferrioxamine intraperitoneally followed by oral infection with virulent resulted in diarrhea, loss of body weight, bacterial colonization and progressive colitis characterized by disruption of epithelial lining, loss of crypt architecture with goblet cell depletion, increased polymorphonuclear infiltration into the mucosa, submucosal swelling (edema), and raised proinflammatory cytokines and chemokines in the large intestine.
View Article and Find Full Text PDFMurine typhus: a re-emerging rickettsial zoonotic disease.
J Vector Ecol
December 2024
Urban and Public Health Entomology Program, Department of Agricultural Science and Plant Protection, Mississippi State University, Mississippi State, MS 39762 U.S.A.
Murine typhus, caused by , is re-emerging in many parts of the world. The disease is also called endemic typhus to differentiate from epidemic typhus (caused by ), and sometimes also named flea-borne typhus. Occasionally, literature sources will include as a causative agent of flea-borne typhus, but illnesses caused by are actually flea-borne spotted fever.
View Article and Find Full Text PDFTyphoid & paratyphoid vaccine development in the laboratory: a review & in-country experience.
Indian J Med Res
December 2024
ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India.
Enteric fever is caused by the infection of Gram-negative bacteria, Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi (S. Paratyphi) A, B and C, through contaminated food and water. The disease almost exclusively affects the populations living in low- and middle-income countries, with the World Health Organization Southeast Asian Region (WHO SEAR) having the highest endemicity.
View Article and Find Full Text PDFGenomic Characterization and Probiotic Properties of Lactiplantibacillus pentosus Isolated from Fermented Rice.
Probiotics Antimicrob Proteins
October 2024
Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570020, India.
Article Synopsis
- * Genome sequencing revealed a 3.7-Mb genome, highlighting important features such as antibiotic resistance and bacteriocin production through bioinformatics.
- * The strain exhibited strong antagonistic effects against several pathogenic bacteria, making it a candidate for future use as a probiotic in the food industry, pending further genetic and functional analysis.
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