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Lacosamide and Levetiracetam Are Not Toxic to the Developing Mouse Brain.
Ann Neurol
October 2024
Department of Neurology, University of Wisconsin, School of Medicine, Madison, WI.
Article Synopsis
- A study investigated the effects of the antiseizure drug lacosamide on neonatal mice, particularly focusing on its neurotoxic potential in combination with levetiracetam.
- * Injections of various treatments were given to the mice, including saline, phenobarbital, lacosamide, levetiracetam, and their combination.
- * Results indicated that while phenobarbital increased apoptotic cell death, neither lacosamide alone nor in combination with levetiracetam showed any significant increase in apoptosis compared to the saline group, implying they may be safer for developing brains.
Levetiracetam Prevents Neurophysiological Changes and Preserves Cognitive Function in the Human Immunodeficiency Virus (HIV)-1 Transactivator of Transcription Transgenic Mouse Model of HIV-Associated Neurocognitive Disorder.
J Pharmacol Exp Ther
September 2024
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota (A.N.E., A.P., S.M.G., S.A.T.); and Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota (S.D.H., C.K.-M., E.K.-M.)
Article Synopsis
- Nearly half of the 39 million people living with HIV are affected by HIV-associated neurocognitive disorder (HAND), which includes symptoms ranging from cognitive impairment to dementia, and currently has no established treatment.
- The HIV protein TAT is believed to contribute to HAND by causing neurotoxicity and resulting in network hyperexcitability that correlates with cognitive decline.
- The study demonstrates that the antiepileptic drug levetiracetam (LEV) can alleviate excitatory synaptic transmission issues and cognitive deficits in mice expressing the TAT protein, suggesting LEV might be a potential treatment for HAND.
Morphological and histopathological changes of maternal levetiracetam on the cerebellar cortex of the offspring of albino rat.
Ultrastruct Pathol
July 2024
Department of Anatomy and Physiology, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Levetiracetam (LEV) is being used by women with reproductive-age epilepsy at a significantly higher rate. The purpose of the study was to assess how levetiracetam treatment during pregnancy affected the offspring's weight and cerebellum. Forty pregnant rats were divided into two groups (I, II).
View Article and Find Full Text PDFCost-effectiveness analysis of HLA-B*15:02 screening before treatment of epilepsy in Indonesia.
Epilepsy Behav
June 2024
Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:
Introduction: Adverse skin reactions due to drugs such as Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) occur in 3% of people receiving anti epileptic drugs (AED). Although SJS/TEN has a low incidence, the mortality and morbidity rates are high. Indonesia has not adopted HLA-B*1502 screening prior to administration of carbamazepine (CBZ), although previous studies found a relationship between HLA-B*1502 and SJS/TEN.
View Article and Find Full Text PDFToxic epidermal necrolysis associated with the use of levetiracetam.
Clin Toxicol (Phila)
March 2024
Clinical Toxicology, Clínica Los Nogales, Bogotá, Colombia.
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