In this study the migration of peritoneal cells was investigated by a fluorescence labelling technique. We found that peritoneal cells migrate to the subcapsular sinus and medulla of the parathymic lymph node (PTLN) and paratracheal lymph node (PTrLN). It was also observed that fluorescence labelled cells possibly granulocytes, macrophages and dendritic cells were found in the B cell follicles of Peyer patches and the dome area after intraperitoneal (ip) labelling. The implication of the migration of antigen presenting cells to the gut on the mucosal immune response is discussed.
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http://dx.doi.org/10.1007/978-1-4615-2930-9_54 | DOI Listing |
Nanomedicine (Lond)
January 2025
Department of Chemistry, The University of Jordan, Amman, Jordan.
Aims: We develop and evaluate copper-based metal-organic frameworks (Cu-MOFs) incorporating cromolyn as a linker to enhance structural stability, drug delivery efficiency, and therapeutic potential, particularly for breast cancer treatment.
Materials & Methods: Two Cu-MOF formulations were synthesized: Cu-MOFs-BDC-DOX (using terephthalic acid) and Cu-MOFs-CROMO-DOX (using cromolyn as a linker). Characterization was performed using SEM/TEM for morphology, and FTIR, XRD, and TGA to confirm structural integrity.
Stem Cell Rev Rep
January 2025
Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland.
Evidence accumulated mitochondria, as the "powerplants of the cell," express several functional receptors for external ligands that modify their function and regulate cell biology. This review sheds new light on the role of these organelles in sensing external stimuli to facilitate energy production for cellular needs. This is possible because mitochondria express some receptors on their membranes that are responsible for their autonomous responses.
View Article and Find Full Text PDFDemography
January 2025
Department of Sociology, University of Stockholm, Stockholm, Sweden.
It is well-known that childbearing is associated with age at migration, but most research has focused on foreign-born women who migrated as adults. Much less is known about male immigrants or immigrants who arrived as children, despite the importance of studying these groups to understand theories of adaptation and socialization. This study addresses these gaps with a case study of Sweden, using longitudinal whole-population data to analyze the role of age at arrival in determining childbearing.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Disruption of the intestinal epithelial barrier results in increased permeability and is a key factor in the onset and progression of Crohn's disease (CD). The protein SPARC is primarily involved in cell interaction and migration, but its specific role in the intestinal epithelial barrier remains unclear. This study demonstrates that SPARC is significantly overexpressed in both CD patients and murine models of colitis.
View Article and Find Full Text PDFMacromol Biosci
January 2025
Department of Pediatrics, Afyonkarahisar Health Sciences University, Afyonkarahisar, 03030, Türkiye.
Chemotherapy is generally given by intravenous (IV) administration which provides higher bioavailability than other systemic routes. However, in the case of lung cancer, the pulmonary (INH) route is the other choice for inhalable formulations. In the study, biochemical and histological parameters of Cabazitaxel (CBZ) free (2 mg kg) and nanoparticle (NP) (2 mg kg CBZ equivalent) formulations are investigated after IV and INH administration in rats.
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