The in vivo strains of the musculus interosseus medius (suspensory ligament) and its rami extensorii (extensor branches) in the forelimb of the horse were determined from angular changes of the metacarpophalangeal and the distal interphalangeal joints. For this purpose, regression models were fitted to strains and joint angle combinations measured in in vitro limb loading experiments. The in vivo strains were computed from the kinematics of 8 horses at the walk, the trot and the canter. It was found that the extensor branches were strained about 1.0% at hoof impact, which indicates that they passively extend the interphalangeal joints just prior to impact and prevent flexion of the pastern joint just thereafter. The maximal strain of the suspensory ligament amounted to 3.4% at the walk, 5.6% at the trot and 6.3% at a slow canter.
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Exp Brain Res
January 2025
Dept. of Neurosurgery, Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA.
Transcranial magnetic stimulation (TMS) has been used for many years to study the pathophysiology of amyotrophic lateral sclerosis (ALS). Based on single- or dual-pulse TMS and EMG and/or single motor unit (MU) recordings, many groups have described a loss of central inhibition as an early marker of ALS dysfunction, reflecting a state of cortical 'hyperexcitability'. This conclusion is not without its detractors, however, leading us to reexamine this issue using 4-pulse TMS, shown previously to be more effective for testing central motor pathway functional integrity.
View Article and Find Full Text PDFNeuroSci
December 2024
Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center Ljubljana, Zaloška cesta 7, 1525 Ljubljana, Slovenia.
In ulnar neuropathy at the elbow (UNE), the degree of neuropathic changes, the sensitivity of needle electromyography (EMG) in individual ulnar muscles, and the utility of individual EMG parameters are controversial. I compared qualitative needle EMG findings in two ulnar-innervated hands muscles and two ulnar-innervated forearm muscles in a group of previously reported UNE patients. Altogether, 170 UNE patients (175 arms) were studied.
View Article and Find Full Text PDFCureus
November 2024
Norton Neuroscience Institute, Norton Healthcare, Louisville, USA.
Hirayama disease (HD) is a rare disorder characterized by insidious asymmetric neurogenic atrophy primarily involving the upper extremities. HD most commonly affects adolescent males and has a favorable prognosis for arrest of progression. Electrodiagnostic (EDX) studies show chronic denervation changes in the distal upper extremity muscles.
View Article and Find Full Text PDFMuscle Nerve
January 2025
International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Introduction/aims: Assessing upper limb muscle strength is important for understanding health outcomes, such as daily function and mortality. Ultrasound (US) is increasingly used to evaluate muscle health, but the relationship between its measures of morphology and isometric strength has not been thoroughly explored in upper limb muscles. The aim of this study was to evaluate the associations between US morphological measures and isometric strength in functionally relevant upper limb muscles in healthy adults.
View Article and Find Full Text PDFEur J Neurol
December 2024
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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