The patient with ulcerative colitis requiring surgery has several options from which to choose. Although the pelvic pouch procedure may be preferred by many patients, in fact, all of the operations have both their advantages and disadvantages. Thus, patients should be fully informed of the various options and participate in the surgical decision making. Surgeons performing elective operations on patients with ulcerative colitis should be experienced with all of the procedures. Only then can they be unbiased in presenting the various options to the patient. Advocates of total proctocolectomy often cite the high complication rates of the Kock and pelvic pouch procedures and condemn these operations on this basis. However, the magnitude of a total proctocolectomy cannot be minimized, and the complication rate of this procedure is significant. On the other hand, total proctocolectomy is often condemned because of the permanent ileostomy and the perceived poor quality of life. This appears to be untrue. Most patients, regardless of which operation is performed, have a high quality of life. This is likely a result of the fact that physical well-being is excellent in most patients, and this may be the primary determinant of quality of life in these patients. It must be accepted, however, that some patients do have difficulties psychologically or physically with an ileostomy. Fortunately, there are several alternatives available for these people.
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http://dx.doi.org/10.1016/s0039-6109(16)46132-3 | DOI Listing |
Mol Med
January 2025
Department of Critical Care Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, Hubei, China.
Background: Macrophages play an important role in the pathogenesis of ulcerative colitis (UC). We will explore the effects of sodium butyrate (SB) on macrophage function.
Methods: The targets of butyric acid were identified using SwissTargetPrediction database and surface plasmon resonance (SPR).
Farm Hosp
January 2025
Servicio de Farmacia, Hospital Universitario La Plana, Castellón, España.
Background: Adalimumab biosimilar MSB11022 (Idacio®) has been approved for the same indications as its originator (Humira®), based on findings from clinical trials in plaque psoriasis. Data on its efficacy and safety in inflammatory bowel disease, however, are scarce.
Methods: Retrospective, observational study of 44 patients with inflammatory bowel disease: 30 were treated with originator adalimumab, five were directly started on MSB11022, and nine switched from originator to biosimilar adalimumab.
Am J Chin Med
January 2025
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China.
Palmatine (PAL) and berberine are both classified as protoberberine alkaloids, derived from several traditional Chinese herbs such as Franch. and Schneid. These compounds are extensively used in treating dysentery and colitis.
View Article and Find Full Text PDFGut
January 2025
Barts Cancer Institute, Queen Mary University of London, London, UK
Background: The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and difficult to predict. This is a major challenge for effective clinical management.
Objective: We aimed to provide accurate AN risk stratification in UC patients with LGD.
Int J Biol Macromol
January 2025
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address:
Steamed Polygonatum sibiricum is widely applied in clinical practice for its tonic effect on gastrointestinal tract. A novel polysaccharide named PSSP-EF was extracted from the steamed roots of Polygonatum sibiricum using hot water extraction, ethanol precipitation, and chromatographic purification. PSSP-EF, with a molecular weight of 2.
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