Concentration of leukotriene C4 (LT C4) in subretinal fluid and plasma of 12 patients with idiopathic retinal detachment has been studied. In 10 cases the subretinal fluid contained LT C4 (0.34 +/- 0.24 ng/ml) and concentration of this substance was about 10 times lower than that observed in plasma (4.05 +/- 0.83 ng/ml). The presence of LT C4 in subretinal fluid may result from retinal damage and it can be considered as an important prognostic factor.
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