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(1) Background: Buffaloes are crucial livestock species for food and service in tropical and subtropical regions. Buffalo genetics, particularly in indigenous Chinese breeds such as the Xiangxi white buffalo (XWB), remains an intriguing area of study due to its unique traits and regional significance. (2) Methods: This investigation utilized the whole-genome sequences of twenty XWBs (newly sequenced), along with eighty published whole-genome sequences of other buffalo breeds (including Guizhou white buffalo, river buffalo, and Chinese buffalo in the Yangtze River).
View Article and Find Full Text PDFTime and headache: Insights into timing processes in primary headache disorders for diagnosis, underlying pathophysiology and treatment implications.
Cephalalgia
November 2024
Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Article Synopsis
- Time plays a critical role in diagnosing headache disorders and understanding their underlying mechanisms, highlighting the need for effective timing analysis in headache research.
- A review of studies covering primary headache types—migraine, tension-type headache, and cluster headache—reveals distinct timing patterns, such as circadian rhythms in migraines and night-time occurrences in cluster headaches.
- Understanding these time patterns can improve the phenotyping, management, and treatment of headache disorders, pointing towards new, personalized approaches in headache care.
Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip.
PeerJ
September 2024
College of Animal Science and Technology, Tarim University, Alar, Xinjiang, China.
Article Synopsis
- - The study investigates the genetic diversity of Kirghiz sheep and their adaptability to the Pamir Plateau by analyzing various sheep breeds and using advanced genetic analysis techniques such as principal component and phylogenetic analysis.
- - Selective signature analysis revealed important genes linked to adaptive traits and production characteristics, including those related to environmental adaptations, wool quality, body size, reproduction, and immunity.
- - The findings aim to enhance local sheep breeding programs by identifying key candidate genes that can improve the resilience and productivity of Kirghiz sheep in harsh conditions.
Nocturnal sleep phenotypes in idiopathic hypersomnia - A data-driven cluster analysis.
Sleep Med
December 2024
Uppsala University, Department of Surgical Sciences, Uppsala, Sweden. Electronic address:
Introduction: The diagnostic process for idiopathic hypersomnia (IH) is complex due to the diverse aetiologies of daytime somnolence, ambiguous pathophysiological understanding, and symptom variability. Current diagnostic instruments, such as the multiple sleep latency test (MSLT), are limited in their ability to fully represent IH's diverse nature. This study endeavours to delineate subgroups among IH patients via cluster analysis of polysomnographic data and to examine the temporal evolution of their symptomatology, aiming to enhance the granularity of understanding and individualized treatment approaches for IH.
View Article and Find Full Text PDFHaploSweep: Detecting and Distinguishing Recent Soft and Hard Selective Sweeps through Haplotype Structure.
Mol Biol Evol
October 2024
Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
Identifying soft selective sweeps using genomic data is a challenging yet crucial task in population genetics. In this study, we present HaploSweep, a novel method for detecting and categorizing soft and hard selective sweeps based on haplotype structure. Through simulations spanning a broad range of selection intensities, softness levels, and demographic histories, we demonstrate that HaploSweep outperforms iHS, nSL, and H12 in detecting soft sweeps.
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