Population predictions suggest that the proportion of elderly people will continue to rise until 1996, will remain constant until 2016, and will continue to rise again. If the current trends continue, the ED will become an increasingly important provider of primary health care for the elderly population. Practitioners, educators, and administrators in emergency medicine should prepare now to meet the growing needs of this population. The high cost and high rate of recidivism by aged ED patients suggest that attention should be paid to appropriateness, continuity, and effectiveness of care. Early social service intervention in the ED may prove beneficial to older patients. In addition, the basic principles of the care of elderly patients should be included in the training curriculum of ED physicians and primary care providers.
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J Prev Alzheimers Dis
January 2025
1Florida Alzheimer's Disease Research Center, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Background: Mild cognitive impairment (MCI) is a clinical diagnosis representing early symptom changes with preserved functional independence. There are multiple potential etiologies of MCI. While often presumed to be related to Alzheimer's disease (AD), other neurodegenerative and non-neurodegenerative causes are common.
View Article and Find Full Text PDFNeurosciences (Riyadh)
January 2025
From the Department of Family and Community Medicine (Mahfouz, Ghazy), College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia, from Alexandria Directorate of Health Affairs (Abdelmoneim), Egyptian Ministry of Health and Population, Alexandria, Department of Public Health and Community Medicine (Abdu), Faculty of Medicine, Mansoura University, Mansoura, from Public Health and Community Medicine (AboElela, Shiba), Faculty of Medicine for Girls, Al-Azhar University, Cairo, Neuroscience Center (Alhazzani), King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
Objectives: To describe age-standardized incidence and disability-adjusted life years (DALYs) of ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in the Kingdom of Saudi Arabia (KSA) from 1990 to 2019 and forecast these variables using the Global Burden of Diseases (GBD) data over the next years (2020-2030).
Methods: Poisson regression models were employed to identify significant changes in incidence rate ratios (IRRs) and DALY rates for different stroke types. For time series models, the autoregressive integrated moving average (ARIMA) and exponential smoothing state space (ETS) models were used for forecasting.
BMJ Open
January 2025
Department of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Introduction: Digital trials are a promising strategy to increase the evidence base for common interventions and may convey considerable efficiency benefits in trial conduct. Although paediatric intensive care units (PICUs) are rich in routine electronic data, highly pragmatic digital trials in this field remain scarce. There are unmet evidence needs for optimal mechanical ventilation modes in paediatric intensive care.
View Article and Find Full Text PDFBiochim Biophys Acta Rev Cancer
January 2025
Central Laboratory, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu, Nanjing, China. Electronic address:
In recent years, with the deepening understanding of the biological mechanisms underlying tumorigenesis, metabolic reprogramming has emerged as a pivotal process in cancer initiation, progression, and treatment resistance, gradually paving the way for new avenues in precision oncology. Natural herb ingredients, characterized by their multi-target engagement, low toxicity, and wide-ranging biological activities, exhibit unique advantages in anti-cancer therapy. Nonetheless, the clinical application of these components has been constrained by issues such as poor solubility, low bioavailability, and inadequate stability when administered through traditional delivery methods.
View Article and Find Full Text PDFDev Biol
January 2025
Developmental Biology & Cancer Department, UCL Great Ormond Street Institute of Child Health, London, UK.
Reichert's membrane (RM) is a basement membrane of gigantic proportions that surrounds the mammalian embryo following implantation. It is part of the parietal yolk sac, which originates from the wall of the preimplantation blastocyst. RM persists from implantation to birth in rodents and analogous structures occur in other mammals, including primates.
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