AI Article Synopsis
- The study examined the effects of treating bovine internal thoracic artery (BITA) collagen with glutaraldehyde (GA) and polyepoxy compounds (PC), focusing on how these treatments alter surface properties.
- The treatment with PC significantly reduced lysine and other amino acid levels, particularly an 80% reduction in lysine content, indicating that PC primarily interacts with lysine residues.
- Both treatments resulted in crosslinking, as shown by an increase in the denaturation temperature, and FTIR analysis revealed no lipid deposition over a 96-day period after implantation.
Article Abstract
Collagen of bovine internal thoracic artery (BITA) was treated with glutaraldehyde (GA) or polyepoxy compounds (PC). This study was to evaluate the surface properties as a result of tissue tanning reaction with PC. The fixation resulted in a significant reduction of available lysine, histidine, and other amino acid residues in PC fixed grafts as compared to fresh pre-fixed arteries. Among them, the lysine (Lys) content was reduced by about 80%, indicating that PC reactions mainly involve with Lys residues. Both PC and GA treatment led to crosslinking as evidenced by the increase in the denaturation temperature. The critical surface tension and the Fourier Transform Infrared Spectrum (FTIR) on a pre-implant and its 96 days explant were evaluated and found to be similar. The FTIR analysis of a pre-implant and the 96 day explant indicated that there was no lipid deposition.
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