The carbamate insecticide ZZ-Aphox induced structural changes of gills, liver, gall-bladder, heart, and notochord of Rana perezi tadpoles.

Arch Environ Contam Toxicol

Dpto. Biología Celular y Anatomía, Universidad de León, Spain.

Published: August 1993

AI Article Synopsis

  • Rana perezi embryos were exposed to carbamate ZZ-Aphox at chronic doses of 0.02% and 0.14% over 9 weeks, showing a clear link between dosage and harmful effects.
  • Survivors exhibited significant damage to vital organs like gills, liver, gall-bladder, heart, and notochord, with some damages being recoverable while others were permanent.
  • The study highlights concerns over how the pesticide might disrupt the synthesis of critical connective tissues in these organisms.

Article Abstract

Embryos of Rana perezi were kept under laboratory conditions and treated with carbamate ZZ-Aphox at chronic doses of 0.02% and 0.14% for 9 weeks. Both the histological study and the analysis of mortality show a direct relationship between the dosage and the effects of the pesticide. The histological study of the survivors over 56 days show damages in gills, liver, gall-bladder, heart, and notochord. Damages on the epithelial of gills (on their distal portion) and gall-bladder recover over a few days, whereas those provoked on the compacting of the hepatic parenchyma and the hepatocytes, the auricle and the perintocohordal collagenic fibers alter their structure in a lasting way. Potentials of such alterations are discussed, with special reference to the possible interference of the pesticide on the successful synthesis of the supporting connective sheaths.

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http://dx.doi.org/10.1007/BF00212129DOI Listing

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