Clozapine represents the first significant advance in the pharmacotherapy of schizophrenia since development of phenothiazine antipsychotic drugs in the 1950s and 60s, yet only about 10% of potential patients nationwide are taking the medication.
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Catatonia is one of the most severe psychiatric syndromes, and clinical symptoms and etiology are very heterogeneous. When accompanied by autonomic instability and hyperthermia it’s termed malignant catatonia, which left untreated is associated with significant morbidity and mortality. First-line treatment is high dose benzodiazepines, followed by electroconvulsive therapy (ECT), in case of non-response.
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Screen printed 3D microfluidic paper-based and modifier-free electroanalytical device for clozapine sensing.
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Department of Psychiatry, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
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