Examination of B-endorphin blood serum levels of 27 girls and young women with premature ovarian function depression was performed Patients were not pregnant before. The 54 young, regularly menstruating, healthy women composed the control group, who were divided into two groups according to the menstrual phase. Levels of B-endorphin were lower in examined group than in control one. High levels of B-endorphin were found at the patients with secondary diagnosed insensitive ovary syndrome. This fact suggest that examination of B-endorphin levels can be useful for clinical differentiation of insensitive ovary syndrome and premature ovarian function depression.
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