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The ethanolic extract of Rhaphidophora peepla prevents inflammation by inhibiting the activation of Syk/AKT/NF-κB and TAK1/MAPK/AP-1.
Phytomedicine
January 2025
Department of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon 16419, Republic of Korea; Department of Biocosmetics, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address:
Background: Inflammation is the body's innate reaction to foreign pathogens and serves as a self-regulating mechanism. However, the immune system can mistakenly target the body's own tissues, triggering unnecessary inflammation. For millennia, medicinal plants have been employed for the treatment of diseases.
View Article and Find Full Text PDFImmunopharmacological Insights into Cordyceps spp.: Harnessing Therapeutic Potential for Sepsis.
Curr Pharm Des
December 2024
Department of Life Science, Parul Institute of Applied Science, Parul University, Vadodara, Gujarat, India.
Cordyceps spp. (CS), a well-known medicinal mushroom that belongs to Tibetan medicine and is predominantly found in the high altitudes in the Himalayas. CS is a rich reservoir of various bioactive substances including nucleosides, sterols flavonoids, peptides, and phenolic compounds.
View Article and Find Full Text PDFEffect of Donor/Recipient ABO Mismatch on Outcome of Allogenic Hematopoietic Stem Cell Transplantation in Children: Single-center Study.
J Pediatr Hematol Oncol
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Pediatric Hematology/Oncology and Bone Marrow Transplantation Unit.
ABO blood group mismatch between donor and recipient is thought to be associated with several immunopharmacological complications but is not considered a major contraindication to allogeneic hematopoietic stem cell transplantation (HSCT). However, the impact of such a mismatch on overall survival, transplant-related mortality, graft-versus-host disease, and time to neutrophil and platelet engraftment seems to be conflicting. This retrospective cohort was carried out on children and adolescents who underwent allogenic HSCT between January 2016 and January 2023.
View Article and Find Full Text PDFFucosterol isolated from Sargassum horneri attenuates allergic responses in immunoglobulin E/bovine serum albumin-stimulated mast cells and passive cutaneous anaphylaxis in mice.
Int Immunopharmacol
April 2024
Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Republic of Korea; Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, Republic of Korea. Electronic address:
Allergic diseases have become a serious problem worldwide and occur when the immune system overreacts to stimuli. Sargassum horneri is an edible marine brown alga with pharmacological relevance in treating various allergy-related conditions. Therefore, this study aimed to investigate the effect of fucosterol (FST) isolated from S.
View Article and Find Full Text PDFResearch Note: Isolation and immunomodulatory activity of bursal peptide, a novel peptide from avian immune system developments.
Poult Sci
February 2024
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China. Electronic address:
The bursa of Fabricius (BF) is pivotal for B lymphocyte ontogenesis. In the present investigation, a novel bursal peptide, designated BP7, was extracted from BF and was found to stimulate colony-forming unit pre-B (CFU pre-B) formation at various concentrations (1 μg/mL, P < 0.05; 5 μg/mL, P < 0.
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