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Optimization of Basophil Activation Test in the Diagnosis and Qualification for Allergen-Specific Immunotherapy in Children with Respiratory Allergy to the House Dust Mite .
Int J Mol Sci
September 2024
Centre of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-503 Krakow, Poland.
Article Synopsis
- - The study optimized a basophil activation test (BAT) to improve detection of house dust mite (HDM) allergy in children with allergic respiratory diseases, involving 32 children (13 girls and 19 boys) aged 4-17, and a control group of 32 children with other types of allergies.
- - The BAT was conducted using various allergen concentrations to determine the best cut-off point for distinguishing between HDM-allergic and non-allergic individuals, finding that a cut-off of 9.76% activated basophils at 2.25 ng/mL yielded high sensitivity (90.6%) and perfect specificity (100%).
- - The results were highly consistent with other allergy testing methods, showing strong
Utility of silver birch and house dust mite extracts derived from licensed sublingual tablets for nasal allergen challenge.
Clin Transl Allergy
May 2024
Department of Allergy, Royal Brompton & Harefield Hospitals NHS Trust, London, UK.
Background: Nasal allergen challenge (NAC) is used to investigate the effects of allergen exposure and assess treatment efficacy in allergic rhinitis (AR). This study aims to establish dose-responses to NAC using licensed silver birch (SB) pollen and house dust mite (HDM) sublingual tablets as sources of the allergen extracts in participants with AR.
Methods: Sixteen volunteers with HDM-induced perennial AR and 15 volunteers with SB pollen-induced seasonal rhinitis underwent a graded up-dosing NAC with extracts derived from HDM allergen (Acarizax®) and SB (Itulazax®) tablets, respectively.
A Clinical Approach of Allergic Rhinitis in Children.
Children (Basel)
September 2023
Pediatric Respiratory Unit, Pediatric Department, University of Crete, 70013 Heraklion, Greece.
Allergic rhinitis is an important disease with a global footprint and a growing prevalence, affecting children and adults. Although it is commonly under-diagnosed and under-treated, it causes important social and economic effects (diminished quality of life, poor academic performance, escalated medical visits, heightened medication usage, and effects in other chronic conditions, e.g.
View Article and Find Full Text PDFLocal allergic rhinitis in children: Clinical characteristics and role of basophil activation test as a diagnostic tool.
Int J Pediatr Otorhinolaryngol
September 2023
Allergy Pediatric Unit, Complexo Hospitalario Universitario, A Coruña, Spain. Electronic address:
Background: Local allergic rhinitis (LAR) is a condition involving a localized nasal allergic response in absence of systemic atopy. Most studies on LAR have been performed in adults. We aimed to describe clinical characteristics of LAR pediatric patients, its clinical evolution over a 7-year follow-up period and to study the role of basophil activation test (BAT), for its diagnosis.
View Article and Find Full Text PDFInflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge.
J Exp Med
September 2023
Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
Innate mononuclear phagocytic system (MPS) cells preserve mucosal immune homeostasis. We investigated their role at nasal mucosa following allergen challenge with house dust mite. We combined single-cell proteome and transcriptome profiling on nasal immune cells from nasal biopsies cells from 30 allergic rhinitis and 27 non-allergic subjects before and after repeated nasal allergen challenge.
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