The sophisticated analysis of and growing information on the human brain requires that acquisition, dissection, storage and distribution of rare material are managed in a professional way. In this publication we present the concept and practice of our brain bank. Both brain tissue and information are handled by standardized procedures and flow in parallel from pathology to neuropathology and neurochemistry. Data concerning brain material are updated with clinical information gained by standardized procedures.
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Correction to: Interplay between androgen and CXCR4 chemokine signaling in myelin repair.
Acta Neuropathol Commun
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UMR1195, "Diseases and Hormones of the Nervous System", Inserm and University Paris-Saclay, 80, Rue du General Leclerc, Kremlin-Bicetre,, 94276, Orsay, France.
The severity of behavioural symptoms in FTD is linked to the loss of GABRQ-expressing VENs and pyramidal neurons.
Neuropathol Appl Neurobiol
June 2022
Department of Pathology, Amsterdam Neuroscience, Amsterdam University Medical Centre, Amsterdam, Netherlands.
Aims: The loss of von Economo neurons (VENs) and GABA receptor subunit theta (GABRQ) containing neurons is linked to early changes in social-emotional cognition and is seen in frontotemporal dementia (FTD) due to C9orf72 repeat expansion. We investigate the vulnerability of VENs and GABRQ-expressing neurons in sporadic and genetic forms of FTD with different underlying molecular pathology and their association with the presence and severity of behavioural symptoms.
Methods: We quantified VENs and GABRQ-immunopositive neurons in the anterior cingulate cortex (ACC) in FTD with underlying TDP43 (FTLD-TDP) (n = 34), tau (FTLD-tau) (n = 24) or FUS (FTLD-FUS) (n = 8) pathology, neurologically healthy controls (n = 12) and Alzheimer's disease (AD) (n = 7).
The bvFTD phenocopy syndrome: a case study supported by repeated MRI, [F]FDG-PET and pathological assessment.
Neurocase
April 2021
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental factors underlie phFTD. We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD.
View Article and Find Full Text PDFIntracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis.
Stroke
February 2018
From the Department of Neurology and Neurosurgery (M.D.L., R.K., G.J.E., Y.M.R.), Hubrecht Institute-KNAW, and Division of Heart and Lungs, Department of Medical Physiology (J.B.), University Medical Center Utrecht, the Netherlands (M.D.L., M.W.V., M.P.C., J.B.); Department of Genetics, University Medical Center Groningen, University of Groningen, the Netherlands (J.J.d.B.-B.); Netherlands Institute for Neuroscience, Amsterdam (N.B.B.); and Division of Pediatrics, Wilhelmina Children's Hospital, Utrecht, the Netherlands (M.M.).
Background And Purpose: Genome-wide association studies significantly link intracranial aneurysm (IA) to single-nucleotide polymorphisms (SNPs) in 6 genomic loci. To gain insight into the relevance of these IA-associated SNPs, we aimed to identify regulatory regions and analyze overall gene expression in the human circle of Willis (CoW), on which these aneurysms develop.
Methods: We performed chromatin immunoprecipitation and sequencing for histone modifications H3K4me1 and H3K27ac to identify regulatory regions, including distal enhancers and active promoters, in postmortem specimens of the human CoW.
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