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Abdominal pain as a novel manifestation in children with PCDH19-related epilepsy: A case report.
Medicine (Baltimore)
January 2025
Department of Neonatal, Children's Hospital Affiliated to Shandong University/Jinan Children's Hospital, Jinan, Shandong, China.
Rationale: PCDH19-related epilepsy manifested various clinical features, including febrile epilepsy, with or without intellectual disability, and psych-behavioral disorders. However, there are few studies demonstrating abdominal pain as the first symptom.
Patient Concerns: A 3-year-old Chinese girl presented with clustered seizures of fever sensitivity accompanied by abdominal pain.
Modulation of Albumin Esterase Activity by Warfarin and Diazepam.
Int J Mol Sci
October 2024
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Torez 44, 194223 St. Petersburg, Russia.
Data are accumulating on the hydrolytic activity of serum albumin towards esters and organophosphates. Previously, with the help of the technology of proton nuclear magnetic resonance (H NMR) spectroscopy, we observed the yield of acetate in the solution of bovine serum albumin and -nitrophenyl acetate (NPA). Thus, we showed that albumin possesses true esterase activity towards NPA.
View Article and Find Full Text PDFPerinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams.
J Toxicol Sci
November 2024
Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd.
We propose a modified Comparative Thyroid Assay (CTA, USEPA) utilizing a smaller number of Sprague-Dawley rats (N=10/group) that assesses brain thyroid hormone (TH) concentrations and periventricular heterotopia while maintaining assay sensitivity. Our recent findings demonstrated that a prenatal test cohort of the modified CTA detected a dose-dependent decrease in maternal serum T3 (up to -26%) and T4 (up to -44%) with sodium phenobarbital (NaPB) exposure at 1000 ppm and 1500 ppm, equivalent to intakes of 60 and 84 mg/kg/day, respectively. On gestation day (GD) 20, fetuses exhibited reduced serum (-26%) and brain (-29%) TH concentrations, although these reductions were not dose dependent.
View Article and Find Full Text PDFEvolving treatment strategies for early-life seizures in Tuberous Sclerosis Complex: A review and treatment algorithm.
Epilepsy Behav
December 2024
Division of Child Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:
Tuberous sclerosis Complex (TSC) is a genetic disorder characterized by multisystem involvement, with epilepsy affecting 80-90% of patients, often beginning in infancy. Early-life seizures in TSC are associated with poor neurodevelopmental outcomes, underscoring the importance of timely and effective management. This review explores the evolving treatment landscape for TSC-associated seizures in young children, focusing on three recently approved or license-expanded therapies: vigabatrin, everolimus, and cannabidiol.
View Article and Find Full Text PDFInforming the risk assessment related to lactation and drug exposure: A physiologically based pharmacokinetic lactation model for pregabalin.
CPT Pharmacometrics Syst Pharmacol
November 2024
Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Article Synopsis
- Breastfeeding is crucial for childhood development, but there’s limited knowledge on the risks of infant drug exposure through human milk, highlighting the need for better understanding in clinical decision-making.
- A study expanded a lactation modeling framework using pregabalin to simulate drug transfer into human milk, incorporating adult and pediatric pharmacokinetics to examine infant exposure.
- Results from the modeling showed that with a maternal dose of 150 mg twice daily, there was an estimated relative infant dose of about 7%, with peak infant plasma concentrations occurring in the first two weeks of life.
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