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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial.
JMIR Res Protoc
January 2025
Graduate Program of Psychiatry and Behavioral Sciences, Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Background: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition emerging in early childhood, characterized by core features such as sociocommunicative deficits and repetitive, rigid behaviors, interests, and activities. In addition to these, disruptive behaviors (DB), including aggression, self-injury, and severe tantrums, are frequently observed in pediatric patients with ASD. The atypical antipsychotics risperidone and aripiprazole, currently the only Food and Drug Administration-approved treatments for severe DB in patients with ASD, often encounter therapeutic failure or intolerance.
View Article and Find Full Text PDFModelling epidemiological dynamics with pseudo-recovery via fractional-order derivative operator and optimal control measures.
PLoS One
January 2025
Department of Pure and Applied Mathematics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
In this study, a new deterministic mathematical model based on fractional-order derivative operator that describes the pseudo-recovery dynamics of an epidemiological process is developed. Fractional-order derivative of Caputo type is used to examine the effect of memory in the spread process of infectious diseases with pseudo-recovery. The well-posedness of the model is qualitatively investigated through Banach fixed point theory technique.
View Article and Find Full Text PDFRussia is a country with a high incidence of tick-borne encephalitis (TBE). In northwestern regions of Russia, 110 TBE cases were registered in 2021. The largest numbers of TBE cases were registered in the Arkhangelsk region and St.
View Article and Find Full Text PDFNon-linear relationship between built environment and non-motorized travel efficiency under the traffic micro-circulation model.
PLoS One
January 2025
School of Architecture and Urban Planning, Lanzhou Jiaotong University, Gansu, Lanzhou, China.
The built environment is an important determinant of travel demand and mode choice. Studying the relationship between the built environment and transportation usage can support and assist traffic policy interventions. Previous studies often assumed that this relationship is linear; however, the impact of the built environment on non-motorized travel efficiency may be more complex than the typically modeled linear relationships.
View Article and Find Full Text PDFDiet, lifestyle and telomere length: using Copula Graphical Models on NHANES data.
Aging (Albany NY)
January 2025
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands.
Telomere length has been related to human health and ageing in multiple studies. However, these studies have analyzed a small set of variables, according to pre-formulated hypotheses. We used data from NHANES 1999-2002 to perform a preregistered cross-sectional analysis.
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