Study of the effect of aluminium, fluoride-ions and fluoroaluminium on the passive transport of Ca2+ through the plasma membrane of the myometrium cells has shown that 10 microM of Al3+, 1 mM of F- and the both ions taken in the mentioned concentrations do not affect this process. At the same time 10 mM of F- as well as 10 microM of Al3+ together with 10 mM of F- inhibit a passive output of calcium from vesicles. The results obtained suppose that inhibitory regulation of the passive transport of calcium in the myometrium sarcolemma is executed through Gi-protein.
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Mucosal Immunol
January 2025
Weill Cornell Medicine Department of Pediatrics, Division of Infectious Disease, New York, NY, USA. Electronic address:
Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic strategies that deliver engineered, potently neutralizing antibodies directly into the infant intestine through breast milk could provide enhanced antimicrobial protection for neonates.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
School of Chemistry and Materials Science, Jiangsu Key Laboratory of New Energy Devices & Interface Science, Nanjing University of Information Science & Technology, Ning-Liu Road 219, Nanjing 210026, China.
Radiative cooling, a passive cooling technology, functions by reflecting the majority of solar radiation (within the solar spectrum of 0.3-2.5 μm) and emitting thermal radiation (within the atmospheric windows of 8-13 μm and 16-20 μm).
View Article and Find Full Text PDFDrug Deliv Transl Res
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, 1 Khartoum Square, Azarita, P.O. Box 21521, Alexandria, Egypt.
Cardiovascular diseases as myocardial infarction (MI) represent a major cause for morbidity and mortality worldwide. Even though, patients who survive MI are susceptible to high risk of heart failure. This is mainly attributed to the major loss of cardiomyocytes and limited regenerative potential of myocardium.
View Article and Find Full Text PDFNeurochem Res
January 2025
Drosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.
This review explores the intricate connections between Drosophila models and the human blood-brain barrier (BBB) with nanoparticle-based approaches for neurological treatment. Drosophila serves as a powerful model organism due to its evolutionary conservation of key biological processes, particularly in the context of the BBB, which is formed by glial cells that share structural and functional similarities with mammalian endothelial cells. Recent advancements in nanoparticle technology have highlighted their potential for effective drug delivery across the BBB, utilizing mechanisms such as passive diffusion, receptor-mediated transcytosis, and carrier-mediated transport.
View Article and Find Full Text PDFPeerJ
January 2025
Chinese University of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China.
The fruits of Retz. (FRL) have a long history of medicinal use, known for their rich composition of flavonoids, polyphenols, amino acids, sugars, and other bioactive compounds. FRL exhibits pharmacological effects such as antioxidant, antiviral, antibacterial, and antitumor activities, making it a valuable resource with significant development potential in both the food and pharmaceutical industries.
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