Using high-performance liquid chromatography, we compared tissue levels of dexamethasone in the aqueous, vitreous, retina, and choroid of rabbits, 1 and 4 hours following subconjunctival or retrobulbar injection. One hour following injection, dexamethasone levels in all of these tissues were similar in both the subconjunctival and retrobulbar groups. Four hours following injection, the concentrations in the two groups also were similar, except in the choroid, in which the subconjunctival injection yielded significantly lower dexamethasone levels than the retrobulbar injection. Tissue steroid levels were comparable ipsilateral and contralateral to the injected eyes in both treatment groups after 4 hours, except in the retina, in which the levels were lower in the contralateral eye after subconjunctival injection. These data suggest that dexamethasone absorption and delivery is predominantly hematogenous following both subconjunctival and retrobulbar injection, especially in highly vascular tissues, such as the choroid. Hematogenous delivery of dexamethasone appears to peak earlier in the choroid and presumably in other intraocular tissues following subconjunctival injections, while retrobulbar injections provide more steady, long-term delivery.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Peribulbar vs. incisionless sub-Tenon's blocks: a retrospective cohort study.
Eur J Med Res
December 2024
Department of Anesthesiology and Reanimation, Faculty of Medicine, Osmangazi University, Büyükdere Mh, Odunpazarı, 26040, Eskişehir, Turkey.
Background: Ophthalmic procedures are increasingly being performed under regional anesthesia techniques such as peribulbar and incisionless sub-Tenon's blocks. The aim is to compare peribulbar block with incisionless sub-Tenon's block in terms of perioperative complications in patients who underwent cataract and vitreoretinal surgeries.
Methods: The patients who underwent cataract or vitroretinal surgery under peribulbar block or incisionless sub-Tenon's block were included in the study.
Retrobulbar Hematoma: Presentation, Management, and Visual Outcomes.
J Craniofac Surg
December 2024
Division of Plastic and Reconstructive Surgery, R. Adams Cowley Shock Trauma Center.
Retrobulbar hematoma (RH) is a diagnostic and therapeutic emergency that may cause permanent vision loss. Lateral canthotomy and cantholysis (LCC) is typically performed when IOP is elevated or vision is compromised. The authors describe the outcomes of the largest cohort of patients with RH to date.
View Article and Find Full Text PDFPattern of Ophthalmic Injuries in Patients With Maxillofacial Fractures at a Tertiary Care Centre in Central India.
Dent Traumatol
December 2024
Department of Ophthalmology, Shyam Shah Medical College, Rewa, India.
Introduction: Maxillofacial injuries are usually associated with ophthalmic injuries that may be mild to severe, and may even result in loss of integrity of the orbital skeleton and impairment of the visual apparatus.
Aim: To evaluate the pattern of ophthalmic injuries associated with maxillofacial fractures in patients who reported to a tertiary care hospital, associated with a medical college in M.P, India.
Do We Need to Hold Aspirin Before Cataract Surgery? A Systematic Review and Meta-Analysis of 65,196 Subjects.
Semin Ophthalmol
February 2025
Department of Ophthalmology, Hamad Medical Corporation, Doha, Qatar.
Purpose: Cataract surgery is a common operation, typically carried out on older adults who have many comorbid medical conditions. Many of these patients may be undergoing aspirin therapy for diverse cardiovascular causes. Nevertheless, there is ongoing controversy regarding the administration of aspirin therapy during the perioperative period, as there are concerns regarding the risk of bleeding problems compared to thromboembolic events.
View Article and Find Full Text PDFUnilateral retrobulbar haemorrhage in a cat secondary to suspected anticoagulant rodenticide intoxication.
Vet Med Sci
July 2024
Veterinary Emergency Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea.
Article Synopsis
- * Diagnostic tests revealed increased pressure in the left eye and prolonged coagulation panels, indicating severe anemia and the presence of blood in the eye socket from retrobulbar fluid.
- * The kitten received treatments including surgery to relieve pressure, blood transfusions, and medications, resulting in improved health over 14 days, although it suffered from permanent optic nerve damage and blindness.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!