The active oviductal transportation capacity was studied in 73 infertile women by the use of a new deposition technique of radioactive particles into the internal cervical os. The main reason for this study was that a previous observation had shown that such a transportation capacity was lacking in 41% of the infertile patients with a normal hysterosalpingogram. The examination was performed in the immediate preovulatory phase, i.e. on days -3 to 0 before the ovulation, as measured by the basal body temperature during two preceding cycles. The deposition of 99mTc-labelled albumin particles of 0.2-1.0 micron at the internal cervical os and the interpretation of the radionuclide images are described in detail. The results show that the bilateral active tubal transportation capacity was present in 42 patients. An impaired transportation capacity was diagnosed in 22 patients. In 9 patients, the particles never reached the uterine cavity, or all activity leaked back to the vagina.
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http://dx.doi.org/10.1159/000292590 | DOI Listing |
J Hazard Mater
December 2024
College of Natural Resources and Environment, Northwest A&F University, Yangling 712100, China; Key Laboratory of Plant Nutrition and the Agro-environment in Northwest China, Ministry of Agriculture, Yangling 712100, China. Electronic address:
The interactions between microplastic-derived dissolved organic matter (MPs-DOM) and heavy metals (Cu, Pb, and Cd) regulate the complex environmental transport behavior of pollutants in terrestrial and aquatic environments. In this study, fluorescence excited emission matrix spectroscopy combined with parallel factor analysis (EEM-PARAFAC) and electrospray ionization coupled Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) were employed to investigate the complexation mechanism of MPs-DOM with heavy metals, as well as the effects of different environmental occurrences of MPs-DOM on the transport behaviors of heavy metals in saturated porous medium. The findings demonstrated that MPs-DOM, particularly humic-like substances containing aromatic structures and various oxygen functional groups, could form stable complexes with heavy metals.
View Article and Find Full Text PDFNeuropathol Appl Neurobiol
February 2025
Department of Neurology, Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.
Aims: Sarcoendoplasmic reticulum Ca-ATPase 2 (SERCA2), encoded by ATP2A2, is a key protein involved in intracellular Ca homeostasis. The SERCA2a isoform is predominantly expressed in cardiomyocytes and type I myofibres. Variants in this gene are related to Darier disease, an autosomal dominant dermatologic disorder, but have never been linked to myopathy.
View Article and Find Full Text PDFThe marginal wells in low-permeability oil fields are characterized by small storage size, scattered distribution, intermittent production, etc. The construction of large-scale gathering pipelines has large investment. So the current production mode is featured by single well tank oil storage, oil tank truck transportation and manual tank truck scheduling.
View Article and Find Full Text PDFImmunometabolism (Cobham)
January 2025
Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
The approval of chimeric antigen receptor (CAR) T cell therapies for the treatment of hematological cancers has marked a new era in cancer care, with seven products being FDA approved since 2017. However, challenges remain, and while profound effects are observed initially in myeloma, the majority of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immune evasion mechanisms, and poor infiltration and persistence.
View Article and Find Full Text PDFLangmuir
January 2025
College of Physical Science and Technology, Yangzhou University, Yangzhou 225002, China.
Porous nanomaterials have shown great promise in many desalination applications. Zeolite nanotubes, featuring abundant but inhomogeneous nanopores on their surface, have been recently synthesized in experiments; however, their capacity for desalination is not yet understood. In this work, we use molecular dynamics simulations to investigate the capability of assembled zeolite nanotube membranes to perform in desalination applications due to their inherent multiscale porous properties.
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