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- A 38-year-old woman experienced difficulty walking and focal seizures, showing signs of cerebellar dysfunction and spastic lower limbs, while having a long history of epilepsy treatment since the age of 20.
- An MRI and MR spectroscopy indicated significant brain changes, including elevated lactate levels, suggesting a mitochondrial disorder.
- Due to financial constraints preventing genetic testing, she was diagnosed with MELAS and switched to alternative treatments to manage her condition.
Attenuation of mitochondrial refractory epilepsy in rotenone corneal kindling model of drug resistance by idebenone: An approach to bypass mitochondrial complex I.
Epilepsy Res
November 2024
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India. Electronic address:
Objective: To assess the potential of bypassing mitochondrial complex I with idebenone to overcome drug resistance in a Rotenone corneal kindling (RCK) mouse model of mitochondrial refractory epilepsy.
Material And Method: Resistance was developed by administering rotenone 2.5 mg/kg intraperitoneally once and corneal kindling twice daily.
Targeted apoptosis of senescent cells by valproic acid alleviates therapy-induced cellular senescence and lung aging.
Phytomedicine
December 2024
Laboratory of Intensive Care, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou, PR China. Electronic address:
Background: Accumulation of senescent cells in tissues and their downstream effect programs have emerged as key drivers of aging and age-associated pathologies. Recent progresses in senotherapeutics indicated that either selectively killing senescent cells with senolytics or suppressing the senescence-associated secretory phenotype (SASP) secretion using senomorphics contributes to extending of the healthy lifespan and alleviating numerous age-related disorders in mice.
Purpose: However, the potential side-effects and long-term cytotoxicity of the above novel compounds have not yet been determined.
Delving into the Complexity of Valproate-Induced Autism Spectrum Disorder: The Use of Zebrafish Models.
Cells
August 2024
Department of Neurobiology and Molecular Medicine, IRCCS Stella Maris Foundation, 56128 Pisa, Italy.
Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental condition with several identified risk factors, both genetic and non-genetic. Among these, prenatal exposure to valproic acid (VPA) has been extensively associated with the development of the disorder. The zebrafish, a cost- and time-effective model, is useful for studying ASD features.
View Article and Find Full Text PDFAcetyl-l-carnitine alleviates valproate-induced autism-like behaviors through attenuation of hippocampal mitochondrial dysregulation.
Neuroscience
October 2024
Neurophysiology Research Center, Shahed University, Tehran, Iran. Electronic address:
This study aimed to evaluate the potential benefits of acetyl-L-carnitine (ALCAR) in the context of valproate-induced autism. After prenatal exposure to valproate (VPA; 600 mg/kg, i.p.
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