In 1992 a seroepidemiological survey regarding the immune status for poliomyelitis was carried out amongst the population of the city of Utrecht: Dutch people born before 1945 and migrant workers and their families of all ages. Migrant workers and their families were well protected against poliomyelitis, using the WHO criteria (titre > or = I:8). The Dutch people born before 1945 were also well protected. Protection of Dutch people born before 1945 was better as their socioeconomic status was lower.
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Environ Health Perspect
January 2025
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Background: Uterine fibroids disproportionately affect Black women, and exposure to chemicals from hair relaxers or straighteners ("straighteners") may contribute to fibroid development.
Objectives: We examined the association between straightener use and prevalent young-onset uterine fibroids (diagnosed before age 36 y), as well as incident fibroids (diagnosed age 36-60 y), with a focus on Black women. We also examined differences in associations across birth cohorts as proxies for formulation changes.
Lancet Reg Health West Pac
December 2024
Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Background: The cost-effectiveness of different lung cancer screening strategies has been evaluated from an Australian public health system perspective using static models. In addition, the impact of novel therapies, including immunotherapies and targeted therapies, on the cost-effectiveness of lung cancer screening has not yet been evaluated comprehensively. We evaluated the benefits, harms and cost-effectiveness of a targeted national lung screening program in Australia, accounting for the increasing uptake of novel therapies, which informed the lung cancer screening recommendations of the Australian Medical Services Advisory Committee (MSAC).
View Article and Find Full Text PDFPsychol Med
November 2024
Promenta Research Center, University of Oslo, Oslo, Norway.
Background: Mental disorders and physical-health conditions frequently co-occur, impacting treatment outcomes. While most prior research has focused on single pairs of mental disorders and physical-health conditions, this study explores broader associations between multiple mental disorders and physical-health conditions.
Methods: Using the Norwegian primary-care register, this population-based cohort study encompassed all 2 203 553 patients born in Norway from January 1945 through December 1984, who were full-time residents from January 2006 until December 2019 (14 years; 363 million person-months).
Obesity (Silver Spring)
November 2024
Global Health Institute, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
Objective: Obesity has become a major public health problem worldwide and particularly in China. This study examined the secular trend of overweight and obesity in China over the past 100 years.
Methods: Nationwide data from the China Health and Nutrition Survey and the Chinese General Social Survey were used.
medRxiv
October 2024
University of the Witwatersrand, Perinatal HIV Research Unit, Faculty of Health Sciences, Johannesburg, South Africa; South African Medical Research Council, Cape Town, South Africa.
Background: The neonatal immune system is uniquely poised to generate broadly neutralizing antibodies (bnAbs) and thus infants are ideal for evaluating HIV vaccine candidates. We present the design and safety of a novel glucopyranosyl lipid A (GLA)-stable emulsion (SE) adjuvant admixed with a first-in-infant CH505 transmitter-founder (CH505TF) gp120 immunogen designed to induce precursors for bnAbs against HIV.
Methods: HVTN 135 is a phase I randomized, placebo-controlled trial of CH505TF+GLA-SE or placebo.
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