Tropical spastic paraparesis is an infection caused by human T lymphotropic virus type 1 (HTLV-1). We present the urodynamic findings in 4 female and 1 male patient with tropical spastic paraparesis. All patients underwent synchronous video-pressure-flow urodynamics, while 3 also underwent electromyographic examination. Of the 5 patients 4 presented with detrusor external sphincter dyssynergia and 1 had detrusor hyperreflexia with a coordinated sphincter contraction. The preliminary results of this series suggest that patients with tropical spastic paraparesis and voiding symptoms should undergo urodynamic examination so that diagnosis and appropriate therapy may be instituted.
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http://dx.doi.org/10.1016/s0022-5347(17)35652-5 | DOI Listing |
Curr Pain Headache Rep
January 2025
Department of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
Purpose Of Review: Baclofen, a muscle relaxant that reduces the release of excitatory neurotransmitters in the pre-synaptic neurons stimulating inhibitory neuronal signals in post-synaptic neurons, has been around for over 5 decades. Baclofen is used primarily for spasticity and since 1982, has had a role as an intrathecal agent. In the present investigation, we review research trends and updates on safety and efficacy of intrathecal baclofen (ITB) pumps.
View Article and Find Full Text PDFRetrovirology
December 2024
Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Cytokine
January 2025
Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Human T-lymphotropic virus type 1 (HTLV-1), leads to adult T-cell lymphoma/leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of infected individuals. The virus promotes inflammation, a major factor in chronic disease progression. Probiotics' immune modulation and anti-inflammatory effects present a potential therapeutic intervention for HTLV-1-related conditions.
View Article and Find Full Text PDFCureus
November 2024
Internal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Neurotoxicology
December 2024
Université Catholique de Bukavu (UCB), Center for Tropical Diseases and Global Health (CTDGH), Bukavu, Democratic Republic Congo; University of Fribourg, Faculty of Science and Medicine, Department of Neuroscience and Movement Science, Fribourg, Switzerland.
Introduction: Chronic cassava-derived cyanide poisoning is associated with the appearance of konzo, a tropical spastic paraparesis due to selective upper motor neuron damage. Whether the disease is caused by a direct action of cyanide or its metabolites is still an open question. This preliminary study assessed the neurotoxic effects of thiocyanate (SCN) and cyanate (OCN), two cyanide metabolites hypothesized to be plausible toxic agents in konzo.
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