Rationale And Objectives: The effects of shock waves on experimental tumors in vivo by gadolinium(+)-DTPA-enhanced magnetic resonance imaging (MRI) are assessed.
Methods: Two amelanotic hamster melanomas were implanted in the dorsal skin of 19 hamsters. In experiment 1 (n = 7), MRI of untreated tumors was performed before, and 5 and 15 minutes after intravenous injection of Gd(+)-DTPA. In experiment 2 (n = 12), 200 shock waves were applied on one of the implanted tumors. Magnetic resonance imaging was performed 15 minutes after treatment before, and 5 and 15 minutes after injection of Gd(+)-DTPA.
Results: In experiment 1, signal intensities (SI) of untreated tumors increased after injection of Gd(+)-DTPA. In experiment 2, enhancement was significantly delayed in shock-wave-treated tumors as compared with controls. Histology of the treated tumors revealed vascular damage.
Conclusion: Differences in enhancement between shock-wave-treated and control tumors after injection of Gd(+)-DTPA are interpreted as the consequence of reduced and delayed accumulation of Gd(+)-DTPA in treated tumors due to shock wave induced vascular damage and reduced tumor perfusion.
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