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Social jetlag decreases across the lifespan: A prospective big data analysis of objective sleep metrics.
J Sleep Res
January 2025
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA.
Changes in social zeitgebers across the lifespan affect the interaction between biological and social clocks, potentially contributing to social jetlag. Extant literature suggests a reduction in social jetlag given declining social obligations occurring after retirement, but is limited to self-reported methods and cross-sectional designs. Leveraging longitudinal and ecologically valid data from consumer sleep technology, we analysed objective sleep data from 2439 users of the polysomnography-validated SleepScore mobile application, encompassing 500,415 total nights recorded.
View Article and Find Full Text PDFA Socio-Ecological Approach to Work Performance: A pilot study among Workers with Chronic Skin Diseases.
J Occup Environ Med
November 2024
Objectives: Chronic skin diseases (CSD) may lead to productivity losses. This mixed-methods study investigated symptom severity, social challenges, need for workplace accommodation, sick leave and their association with perceived impaired work performance (IWP) among workers with CSD.
Methods: Data were collected from April to June 2023.
Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualization.
Nucleic Acids Res
January 2025
Kansai Institute for Photon Science, National Institutes for Quantum Science and Technology (QST), 8-1-7 Umemidai, Kizugawa-shi, Kyoto 619-0215, Japan.
Ionizing radiation induces various types of DNA damage, and the reparability and lethal effects of DNA damage differ depending on its spatial density. Elucidating the structure of radiation-induced clustered DNA damage and its repair processes will enhance our understanding of the lethal impact of ionizing radiation and advance progress toward precise therapeutics. Previously, we developed a method to directly visualize DNA damage using atomic force microscopy (AFM) and classified clustered DNA damage into simple base damage clusters (BDCs), complex BDCs and complex double-strand breaks (DSBs).
View Article and Find Full Text PDFThiosemicarbazone-Based Compounds: A Promising Scaffold for Developing Antibacterial, Antioxidant, and Anticancer Therapeutics.
Molecules
December 2024
Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, 90-151 Lodz, Poland.
This paper presents the synthesis and characterization of new thiosemicarbazone derivatives with potential applications as antibacterial, antioxidant and anticancer agents. Six thiosemicarbazone derivatives (L-L5) were synthesized by reacting an appropriate thiosemicarbazide derivative with 2-pyridinecarboxaldehyde. The structures of the obtained compounds were confirmed using mass spectrometry, infrared spectroscopy, and NMR spectroscopy.
View Article and Find Full Text PDFOptimizing Radiation Protection in PET/CT Examinations: Reducing Occupational Exposure During Patient Positioning.
Cureus
December 2024
Department of Emergency and Intensive Care Medicine, Hospital of the University of Occupational and Environmental Health, Fukuoka, JPN.
Objectives The objective of this study was to evaluate the occupational radiation exposure of healthcare workers during positron emission tomography (PET)/CT examinations, focusing on patient positioning and assessing the effectiveness of different radiation protection measures. Methods Thirteen medical workers (physicians, radiological technologists, and nurses) performed PET/CT examinations on 86 patients at a major Japanese hospital from June to August 2019. Occupational doses were measured using a real-time semiconductor dosimeter: RaySafe i2 (Unfors RaySafe, Billdal, Sweden), recording the 1 cm dose equivalent (Hp(10)).
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