AI Article Synopsis
- Microradiographic analysis of bone fragments from patients with osteoradionecrosis revealed two main types of bone resorption: one osteoclastic type with little new bone formation, and another linked to altered osteocyte activity due to infection.
- Affected osteocytes lead to irreversible widening of osteoplasts, particularly around vascularized bone, causing typical polycyclic cavities seen in osteoradionecrosis.
- A third form of bone damage involves significant demineralization connected to saliva or pus accumulation.
Article Abstract
The microradiographic analysis of thick sections of fragments removed from irradiated patients suffering from osteoradionecrosis has made it possible to bring to the fore two types of bone resorption caused by cells: an osteoclastic one not followed by a relevant osteogenesis, and another, pathognomonic of postradic complications, linked with an altered activity of the osteocytes. Those cells, which have been affected, because of a progressive infection, are responsible for an irreversible widening of the osteoplasts, set in the properly vascularized bone regions, in particular in the wall of haversian canals. The coalescence of widened osteoplats causes polycylic cavities which is a typical feature of osteoradionecrosis. A third type of bone postradic damage consists in a massive demineralization, related to the presence of saliva or pus.
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