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Serotonin receptor 5-HT7 modulates inflammatory-associated functions of macrophages.
Cell Mol Life Sci
January 2025
Cellular Neurophysiology, Hannover Medical School, Hannover, Germany.
The hormone and neurotransmitter serotonin regulates numerous physiological functions within the central nervous system and in the periphery upon binding to specific receptors. In the periphery, the serotonin receptor 7 (5-HT7R) is expressed on different immune cells including monocytes and macrophages. To investigate the impact of 5-HT7R-mediated signaling on macrophage properties, we used human THP-1 cells and differentiated them into pro-inflammatory M1- and anti-inflammatory M2-like macrophages.
View Article and Find Full Text PDFNovel therapeutic approaches targeting 5-HT7 receptors outside the central nervous system.
J Recept Signal Transduct Res
January 2025
Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Serotonin (5-HT) is a neurotransmitter found throughout the human body that regulates many physiological events arising from the brain and central nervous system (CNS), such as sleep and appetite. However, it has many other functions in systems outside. In addition to the routine expression of 5-HT7 receptors in CNS regions, such as the pituitary gland, spinal cord, and hippocampus, many studies have reported the expression of these receptors in pathological conditions outside.
View Article and Find Full Text PDFBehavioral Consequences of Hippocampal 5-HT7 Receptors Blockade in Stressed Rats.
Hippocampus
January 2025
Laboratório de Neurobiologia Do Estresse e da Depressão, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Serotonin (5-HT) has long been involved in response to stress and its effect may be, in part, mediated by 5-HT1a and 5-HT7 receptor subtypes in different brain structures. Both pre- and post-synaptic activation of 5-HT1a receptor, respectively, in the rat median raphe nucleus (MnRN) and hippocampus, lead to adaptation to acute inescapable stressors such as restraint and forced swim. 5-HT7 receptor (5HT7r), a stimulatory G-protein coupled receptor, has also been investigated as a possible candidate for mediating stress response.
View Article and Find Full Text PDFThe cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions.
Cell Commun Signal
November 2024
Cellular Neurophysiology, Hannover Medical School, Hannover, Germany.
Background: Homo- and heteromerization of G protein-coupled receptors (GPCRs) plays an important role in the regulation of receptor functions. Recently, we demonstrated an interaction between the serotonin receptor 7 (5-HT7R), a class A GPCR, and the cell adhesion molecule CD44. However, the functional consequences of this interaction on 5-HT7R-mediated signaling remained enigmatic.
View Article and Find Full Text PDFElectroacupuncture alleviates acute myocardial ischemic injury in mice by regulating the β adrenergic receptor and post-receptor protein kinase A signaling pathway.
Acupunct Med
December 2024
Institute of Acupuncture and Meridian, Anhui University of Chinese Medicine, Hefei, China.
Objective: To determine the effect of electroacupuncture (EA) on β-adrenergic receptor (β-AR) and post-receptor protein kinase A (PKA) signaling pathway after acute myocardial ischemia (MI).
Methods: An MI model was established by ligating the left anterior descending coronary artery of wild-type (WT) C57/BL and β-AR mice (heterozygous for β-AR gene deletion). EA treatment was administered at HT5-HT7 or LU9-LU8.
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