Mutagen agents may increase the genetic load of human populations by inducing heritable diseases and cancer. The most effective way of protection is prevention: detection of the mutagenic agents and the regulation of their use. The harm occurred can be visualized by mutational monitoring and epidemiology. The harmful effects of the induced mutations may be reduced to a level accepted by the society with suitable approach and methods. The role of physicians is especially important to fulfil this task.
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Sci Rep
January 2025
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia.
Polycyclic aromatic compounds (PACs) are pervasive environmental contaminants derived from diverse sources including pyrogenic (e.g., combustion processes), petrogenic (e.
View Article and Find Full Text PDFJ Bacteriol
January 2025
Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
a β-proteobacterium, forms a nitrogen-fixing symbiosis with many species of the large legume genus as well as with common bean ( L.). are considered to have evolved nodulation independently from the well-studied α-proteobacteria symbionts of legumes.
View Article and Find Full Text PDFFront Plant Sci
January 2025
Institute of Environmental Systems Biology, College of Environmental Science and Engineering, Dalian Maritime University, Dalian, China.
Introduction: Rice samples exposed to the space environment have generated diverse phenotypic variations. Miniature-inverted-repeat transposable elements (MITEs), often found adjacent to genes, play a significant role in regulating the plant genome. Herein, the contribution of MITEs in regulating space-mutagenic phenotypes was explored.
View Article and Find Full Text PDFEnviron Mol Mutagen
January 2025
Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan.
There is growing recognition across broad sectors of the toxicology community that gene expression biomarkers have the potential to identify genotoxic and nongenotoxic carcinogens through a weight-of-evidence approach, providing opportunities to reduce reliance on the 2-year bioassay to identify carcinogens. In August 2022, a workshop within the International Workshops on Genotoxicity Testing (IWGT) was held to critically review current methods to identify genotoxicants using various 'omics profiling methods. Here, we describe the findings of a workshop subgroup focused on the state of the science regarding the use of biomarkers to identify chemicals that act as genotoxicants in vivo.
View Article and Find Full Text PDFACS ES T Eng
January 2025
Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, San Diego, California 92093, United States.
Microalgae offer a compelling platform for the production of commodity products, due to their superior photosynthetic efficiency, adaptability to nonarable lands and nonpotable water, and their capacity to produce a versatile array of bioproducts, including biofuels and biomaterials. However, the scalability of microalgae as a bioresource has been hindered by challenges such as costly biomass production related to vulnerability to pond crashes during large-scale cultivation. This study presents a pipeline for the genetic engineering and pilot-scale production of biodiesel and thermoplastic polyurethane precursors in the extremophile species .
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