The venous pressure in the saphenous vein at the ankle was measured in ten healthy subjects (5 men, 5 women) aged 19-33 years during supine posture, orthostasis and cycle ergometer exercise (50 W, 50 rpm). Measurements were made at 20, 28 and 36 degrees C at 50% relative humidity. A custom-built setup consisting of two pressure transducers and a differential amplifier was used to compensate for the hydrostatic effects, temperature influences and movement artefacts that disturbed the pressure measurements. Pressure was lowest in the supine position and varied only slightly with the ambient temperature. The mean pressures were 7 (SEM 1) mmHg [0.9 (SEM 0.13) kPa], 7 (SEM 1) mmHg [0.9 (SEM 0.13) kPa], 4 (SEM 1) mmHg [0.5 (SEM 0.13) kPa] at 20, 28 and 36 degrees C. The venous pressure increased when the subjects were passively tilted from a supine to an upright posture. The rate of the increase was smaller at 20 degrees C than at 28 degrees and 36 degrees C. The final level the pressure reached during motionless standing differed slightly. The mean pressures were 76 (SEM 2) mmHg [10.1 (SEM 0.27) kPa], 79 (SEM 7) mmHg [10.5 (SEM 0.93) kPa] and 75 (SEM 3) mmHg [10.0 (SEM 0.40)] at the three temperatures. When starting exercising, venous pressure decreased within the 1st min to a level which remained virtually constant until the end of exercise. However, this level was found to be temperature dependent. It was lowest at 20 degrees C (26 (SEM 3) mmHg [3.5 (SEM 0.40) kPa]) and increased with temperature.(ABSTRACT TRUNCATED AT 250 WORDS)
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Biosens Bioelectron
January 2025
Department of Ophthalmology, Tongji Eye Institute, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China; Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Institute of Optoelectronics, Fudan University, Shanghai, 200438, People's Republic of China; Department of Materials Science & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, People's Republic of China; State Key Laboratory of Integrated Chips and Systems, Frontier Institute of Chip and System, Fudan University, Shanghai, 200438, People's Republic of China. Electronic address:
Technologies that established in vivo evaluations of soft-tissue biomechanics and temperature are essential to biological research and clinical diagnostics, particularly for a wide range of eye-related diseases such as glaucoma. Of importance are advanced bioelectronic devices for high-precise monitoring of intraocular pressure (IOP) and various ocular temperatures, as clinically proven uses for glaucoma diagnosis. Existing characterization methods are temporary, single point, and lack microscale resolution, failing to measure continuous IOP fluctuation across the long-term period.
View Article and Find Full Text PDFJ Mater Chem B
September 2024
Caspian Faculty of Engineering, College of Engineering, University of Tehran, P.O. Box 43841-119, Gilan, Iran.
In this study, we employed a combination of electrospinning and electrospray techniques to fabricate wound dressings with a particle-fiber structure, providing dual characteristics of oxygen-releasing and intrinsic antioxidant properties, simultaneously. The electrospun part of the dressing was prepared from a blend of polycaprolactone/gallic acid--gelatin (GA--GE), enabling intrinsic ROS scavenging. To the best of our knowledge, this is the first time that PCL/GA--GE was fabricated by electrospinning.
View Article and Find Full Text PDFIntensive Care Med Exp
August 2024
Centre de Recherche Clinique du CHU Sherbrooke (CRCHUS), CHUS, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
Background: Infusion of exogenous catecholamines (i.e., norepinephrine [NE] and dobutamine) is a recommended treatment for septic shock with myocardial dysfunction.
View Article and Find Full Text PDFBraz J Phys Ther
August 2024
Department of Health Sciences, Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Background: Migraine may be accompanied by several cervical musculoskeletal dysfunctions, for example an altered performance on the Craniocervical Flexion Test (CCFT). However, CCFT measurement properties are still unclear in patients with migraine.
Objectives: To determine intra- and inter-examiner reliability, construct validity, standard measurement error (SEM), and minimal detectable change (MDC) of the CCFT in patients with migraine.
Micromachines (Basel)
June 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Background: Inherited primary open-angle glaucoma (POAG) in Beagle dogs is a well-established large animal model of glaucoma and is caused by a G661R missense mutation in the gene. Using this model, the study describes early clinical disease markers for canine glaucoma.
Methods: Spectral-domain optical coherence tomography (SD-OCT) was used to assess nine adult, -mutant (median age 45.
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