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Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts.
Respir Care
April 2022
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.
Acute respiratory failure with inadequate oxygenation and/or ventilation is a common reason for ICU admission in children and adults. Despite the morbidity and mortality associated with acute respiratory failure, few proven treatment options exist beyond invasive ventilation. Attempts to develop intravascular respiratory assist catheters capable of providing clinically important gas exchange have had limited success.
View Article and Find Full Text PDFPhase III randomized trial comparing systemic versus intra-arterial oxaliplatin, combined with LV5FU2 +/- irinotecan and a targeted therapy, in the first-line treatment of metastatic colorectal cancer restricted to the liver (OSCAR): PRODIGE 49.
Dig Liver Dis
March 2022
Department of Gastroenterology and GI Oncology, Hopital Européen Georges-Pompidou, Université de Paris, SIRIC CARPEM, France.
Introduction: In patients with unresectable liver metastases from colorectal cancer (CRCLM), systemic doublet or triplet chemotherapy and targeted therapy is considered a standard first-line treatment. Hepatic arterial infusion of oxaliplatin (HAI-ox) generates a high response rate, but this still needs to be confirmed in a randomized trial. We incorporated HAI-ox in doublet or triplet + targeted therapy to validate its efficacy.
View Article and Find Full Text PDFCombined ifosfamide, etoposide and oxalipatin chemotherapy, a low-toxicity regimen for first-relapsed or refractory Hodgkin lymphoma after ABVD/EBVP: a prospective monocentre study on 34 patients.
Br J Haematol
April 2011
Department of Haemato-Oncology, Saint-Louis Hospital, 1 avenue Claude-Vellefaux, Paris Cedex 10, France.
Around 20% of Hodgkin lymphoma (HL) patients are refractory to first-line therapy with ABVD (adriamycin-bleomycin-vinblastine-dacarbazine) or relapse after complete remission. Salvage regimens frequently have delayed courses or require dose-reduction because of haemotoxicity. We evaluated the IVOx (ifosfamide-etoposide-oxaliplatin) salvage regimen in terms of response rate, toxicity and stem-cell mobilization.
View Article and Find Full Text PDF[Preliminary study of intravascular oxygenator in braid in vitro].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
December 2009
Laboratory of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Intravenous membrane oxygenator (IVOX), an artificial lung usually located in vena caval system, can provide extra oxygen outside the lung for patients suffering from respiratory failure. However, gas exchange areas of IVOX are limited because of confined space in caval system. The increase of the diameter of IVOX may impede the return of venous blood to heart, and result in serious low blood pressure.
View Article and Find Full Text PDFExtracorporeal life support.
Semin Pediatr Surg
November 2006
Section of Pediatric Surgery, University of Michigan, Ann Arbor, Michigan 48109-0245, USA.
Extracorporeal life support (ECLS) denotes the use of prolonged extracorporeal cardiopulmonary bypass in patients with acute, reversible cardiac or respiratory failure. As technology has advanced, organ support functions other than gas exchange, such as liver, renal, and cardiac support, have been provided by ECLS, and others, such as immunologic support, will be developed. The future of ECLS will include improvements in devices accompanied by circuit simplification and auto-regulation.
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