A rabbit model of peroxide atherosclerosis was used to examine the new psychotropic drug Mexydol for its angioprotective properties. The agent was found to inhibit atheroarteriosclerotic manifestations such as hyperlipemia, activated lipid peroxidation, lower activity of the antioxidative system and to produce protective effects on the local vascular mechanisms of atherogenesis, by diminishing the severity of aortic lesion.
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Chronic cerebral ischemia (CCI) is one of the most common forms of cerebrovascular disease, which affects a significant number of patients, often leading to disability, cognitive impairment and dementia. The analysis of modern data on the pathogenesis and risk factors for the development of CCI, as well as on the mechanisms of action of Mexidol on various links in the pathogenesis of CCI. A systematic search was conducted in the PubMed, MEDLINE and Google Scholar databases, on Russian and English-language sites with open access publications on the problem of CCI and on the drug Mexidol in the period from 2014 to 2024.
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Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies, Mumbai 56, India. Electronic address:
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Vestn Oftalmol
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