We present two cases of urologic malignancies, transitional cell carcinoma of the bladder and renal cell carcinoma respectively, closely associated to progressive systemic sclerosis. The relationship between such neoplasms and immune disorders is thereof reviewed. Cancer may develop in a context of diminished immunological surveillance. Conversely, autoimmunity can also be secondary to neoplasia and somehow understood as paraneoplastic. Anyway, the cases here reported could be regarded as unusual associations that may reproduce the still unclear connections between immunity and neoplasia.
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