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Phase Characterization and Bioactivity Evaluation of Nucleic Acid-Encapsulated Biomimetically Mineralized ZIF-8.
ACS Appl Mater Interfaces
January 2025
Ian Potter NanoBiosensing Facility, NanoBiotechnology Research Laboratory, School of Science, RMIT University, Melbourne, Victoria 3000, Australia.
Metal-organic frameworks (MOFs) provide diverse applications across a wide range of scientific disciplines, including drug/nucleic acid (NA) delivery. In the subclass of MOFs, zeolitic imidazolate framework-8 (ZIF-8) is well regarded due to its exceptional physicochemical properties. Biomolecules can be encapsulated and released under precise conditions within ZIF, making it an important material for materials science and biomedical applications.
View Article and Find Full Text PDFCytotoxicity and Oxidative Stress Induced by Technology-Critical Elements Traditional Metal Contaminants: An Bioassay Study.
Environ Sci Technol
January 2025
Department of Animal Biosciences, Swedish University of Agricultural Sciences, Box 7028, SE-750 07 Uppsala, Sweden.
Technology-critical elements (TCEs), essential in emerging technologies, are increasingly finding their way into our environment, raising concerns about their sparsely studied behavior and toxicity. To contribute insights into the toxicological aspects, we employed bioassays to investigate the possible cytotoxic effects in four representative cell lines (AR-EcoScreen GR-KO-M1, DR-EcoScreen, MCF7AREc32, VM7Luc4E2) and the potential to induce oxidative stress via the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway for a number of these elements. Nine TCEs, three rare-earth elements (REEs: Gd, Nd, Yb) and six less-studied TCEs (LSTCEs: Ga, Ge, In, Ta, Te, Tl), were selected for this study, along with three well-studied traditional metal contaminants (TMCs: As, Cd, Pb) for comparison.
View Article and Find Full Text PDFDibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.
Nat Prod Bioprospect
January 2025
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.
A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1-11).
View Article and Find Full Text PDF[F]F-FAPI-42 PET dynamic imaging characteristics and multiparametric quantification of lung cancer: an exploratory study using uEXPLORER PET/CT.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, China.
Purpose: To explore the dynamic and parametric characteristics of [F]F-FAPI-42 PET/CT in lung cancers.
Methods: Nineteen participants with newly diagnosed lung cancer underwent 60-min dynamic [F]F-FAPI-42 PET/CT. Time-activity curves (TAC) were generated for tumors and normal organs, with kinetic parameters (K, K, K, K, K) calculated.
Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy.
Invest Ophthalmol Vis Sci
January 2025
University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal.
Purpose: Diabetic retinopathy (DR) is usually diagnosed many years after diabetes onset. Indeed, an early diagnosis of DR remains a notable challenge, and, thus, developing novel approaches for earlier disease detection is of utmost importance. We aim to explore the potential of texture analysis of optical coherence tomography (OCT) retinal images in detecting retinal changes in streptozotocin (STZ)-induced diabetic animals at "silent" disease stages when early retinal molecular and cellular changes that cannot be clinically detectable are already occurring.
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