Giant cell tumors of the talus are very uncommon. Secondary aneurysmal bone cyst changes are well documented in the literature with giant cell tumors being one of the most common underlying lesions. However, no previous case of this combination has been documented in the podiatric literature. The diagnosis of these lesions can be very challenging since they share many common features. Although previous reports describe a higher recurrence rate of giant cell tumors when found in the small bones of the hands and feet, reported cases of this entity in the talus indicate a less aggressive natural history with rare malignant transformation. A case report and review of the literature are presented.
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