The frequency of micronuclei in the buccal mucosa cells have been investigated in healthy persons (donors) and patients with tumors before and after chemotherapy. It has been shown that frequency of micronuclei in the cells of patients before therapy and donors were at the same level. One day after chemotherapy the frequency of micronuclei was elevated 3.2 times.
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Indian J Occup Environ Med
December 2024
Department of Industrial Hygiene and Toxicology, ICMR-Regional Occupational Health Centre (S), NIOH, ICMR Complex, Bengaluru, Karnataka, India.
Background: Beedi rolling is a labor-intensive occupation that can cause a variety of health problems due to prolonged exposure to tobacco dust. This cross-sectional study aimed to assess morbidity, hematological profile, and DNA damage among beedi rollers in Karnataka.
Methods: A total of 153 participants, including 85 beedi and 65 non-beedi rollers, were enrolled in the study.
Toxicol Appl Pharmacol
January 2025
Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501, Japan.
Acetamide is a hepatocarcinogen in rats. We previously revealed that acetamide induces characteristic large micronuclei in rat liver, suggesting the possible involvement of chromosome aberrations in acetamide-induced hepatocarcinogenesis. To elucidate the mechanism of large micronuclei formation, in this study we examined time-dependent changes in rat hepatocytes after administration of acetamide.
View Article and Find Full Text PDFChemosphere
January 2025
Université de Lorraine, CNRS, LIEC, F-57000, Metz, France. Electronic address:
The biotransformation of compounds is a critical point in understanding their toxic effects in both toxicology and ecotoxicology. The objective of this study was to evaluate whether there is a difference in the phytogenotoxic potential of the commercial fungicide Nativo® between non-biotransformed samples and samples biotransformed by swine liver enzymes. The fungicide Nativo is a mixture of Tebuconazole (TEB; 200 g L) and Trifloxystrobin (TRI; 100 g L).
View Article and Find Full Text PDFMutat Res Genet Toxicol Environ Mutagen
January 2025
Health Promotion Program University of Franca, SP, Brazil. Electronic address:
We have studied the presence and frequency of micronuclei in exfoliated oral mucosa cells of full-term newborns and their association with maternal prenatal factors. We report an analytical, observational, cross-sectional, prospective study that includes 97 preterm infants (<37 weeks), 37 newborns from mothers with comorbidities, and 60 newborns from mothers without comorbidities, in a tertiary public hospital. Oral mucosa cells were collected within 24 h after birth.
View Article and Find Full Text PDFEnviron Monit Assess
January 2025
Laboratory of Aquatic Toxicology, Graduate and Research Section, Department of Pharmacy, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional. Unidad Profesional Adolfo López Mateos, Av. Wilfrido Massieu S/N, Delegación Gustavo A. Madero, Ciudad de México, 07738, México.
Water contamination greatly impacts human health. The Metropolitan Area of the Valley of Mexico (MAVM) is one of the most densely inhabited and polluted places globally, with a significant problem being the rising water demand. The research aims to assess the impact of metals such as iron, aluminum, lead, cadmium, and total chromium, among others, in the water of the Madin Dam, a key reservoir in the area's water supply.
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