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Research on transition metals for the multicomponent synthesis of benzo-fused γ-lactams.
RSC Adv
January 2025
Department of Organic Chemistry, Faculty of Chemistry Urmia University Urmia Iran.
Benzo-fused γ-lactams are fundamental in medicinal chemistry, acting as essential elements for various therapeutic agents due to their structural adaptability and capability to enhance biological activity. In their synthesis, transition metals play a pivotal role as catalysts, offering more efficient alternatives to traditional methods by facilitating C-N bond formation through mechanisms like intramolecular coupling. Recent advances have especially spotlighted transition-metal-catalyzed C-H amination reactions for directly converting C(sp)-H to C(sp)-N bonds, streamlining the creation of these compounds.
View Article and Find Full Text PDFPetrophysical assessment of the Hammam Faraun, Matulla and Nubia Reservoirs in the Ashrafi Oil Field, Gulf of Suez.
Sci Rep
January 2025
Geophysics Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
The Hammam Faraun, Matulla, and Nubia formations in the Ashrafi oil field, in the southern Gulf of Suez, Egypt, are key hydrocarbon reservoirs with significant economic importance. These formations, characterized by their favorable reservoir properties and structural settings, play a crucial role in oil and gas accumulation. Their study provides valuable insights into regional petroleum systems and guides exploration and production activities.
View Article and Find Full Text PDFAerial urination suggests undescribed sensory modality and social function in river dolphins.
Behav Processes
January 2025
CetAsia Research Group Ltd., Baysville, Ontario, Canada; Department of Biology, Trent University, Peterborough, Ontario, Canada.
Scent marking through urine spraying is known to aid mate selection, territory marking and chemical communication in terrestrial, but not in aquatic mammals. We quantify an unusual aerial urination behaviour in botos (Inia geoffrensis) and discuss its potential functions. Between 2014 and 2018, we conducted land-based behavioural surveys on wild botos in central Brazil, recording the sequence, duration and social context of aerial urination.
View Article and Find Full Text PDFLeveraging Epigenetic Alterations in Pancreatic Ductal Adenocarcinoma for Clinical Applications.
Semin Cancer Biol
January 2025
Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, 84505 Bratislava, Slovakia. Electronic address:
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by late detection and poor prognosis. Recent research highlights the pivotal role of epigenetic alter- ations in driving PDAC development and progression. These changes, in conjunction with genetic mutations, contribute to the intricate molecular landscape of the disease.
View Article and Find Full Text PDFSpatial Localization of Collagen Hydroxylated Proline Site Variation as an Ancestral Trait in the Breast Cancer Microenvironment.
Matrix Biol
January 2025
Department of Pharmacology & Immunology, Proteomics Center, Medical University of South Carolina, Charleston, SC. Electronic address:
Collagen stroma interactions within the extracellular microenvironment of breast tissue play a significant role in breast cancer, including risk, progression, and outcomes. Hydroxylation of proline (HYP) is a common post-translational modification directly linked to breast cancer survival and progression. Changes in HYP status lead to alterations in epithelial cell signaling, extracellular matrix remodeling, and immune cell recruitment.
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